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Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Virology
2015
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| _version_ | 1867613210378502144 |
|---|---|
| access_status_str | Open Access |
| author | Mbele, Prisca |
| author2 | Chapman, Ros |
| author_browse | Chapman, Ros Mbele, Prisca |
| author_facet | Chapman, Ros Mbele, Prisca |
| author_sort | Mbele, Prisca |
| collection | Thesis |
| description | The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10930 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:31.718Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Virology |
| publisherStr | Division of Virology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10930 Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity Mbele, Prisca Chapman, Ros Williamson, Anna-Lise Medical Virology The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination. 2015-01-02T08:55:22Z 2015-01-02T08:55:22Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/10930 eng application/pdf Division of Virology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Virology Mbele, Prisca Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
| thesis_degree_str | Doctoral |
| title | Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
| title_full | Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
| title_fullStr | Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
| title_full_unstemmed | Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
| title_short | Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
| title_sort | evaluation of a reverse tetracycline inducible system in recombinant bcg to improve stability and immunogenicity |
| topic | Medical Virology |
| url | http://hdl.handle.net/11427/10930 |
| work_keys_str_mv | AT mbeleprisca evaluationofareversetetracyclineinduciblesysteminrecombinantbcgtoimprovestabilityandimmunogenicity |