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Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Public Health and Family Medicine
2015
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| _version_ | 1867613300722761728 |
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| access_status_str | Open Access |
| author | Kampiire, Leatitia |
| author2 | Davies, Mary-Ann |
| author_browse | Davies, Mary-Ann Kampiire, Leatitia |
| author_facet | Davies, Mary-Ann Kampiire, Leatitia |
| author_sort | Kampiire, Leatitia |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11003 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:57.504Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11003 Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa Kampiire, Leatitia Davies, Mary-Ann Includes bibliographical references. According to the Joint United Nations Programme on HIV/AIDS (UNAIDS) South Africa 2010 Country Progress report, 81% of South African children in need of antiretroviral therapy (ART) were receiving treatment which is a 20% increment in treatment access from 2008 to 2009. With increase in access to treatment, understanding drug tolerability, safety and durability is important especially among children whose drug options are limited due to few drugs being available in suitable formulations and the need for refrigeration of some drugs. While there are many paediatric studies on ART durability in the developed world, data from the developing world are limited. There is therefore a need to understand the drug-specific probability of and reasons for drug stops or changes among children initiated on ART in South Africa. This knowledge could help in optimisation of use of firstline ART in order to maximise time on first-line therapy and thereby maintain simplicity of programs (program-level benefit) and save alternative drugs for situations of toxicity and virological failure (individual benefit). 2015-01-02T09:17:54Z 2015-01-02T09:17:54Z 2013 Master Thesis Masters MPH http://hdl.handle.net/11427/11003 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Kampiire, Leatitia Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa |
| thesis_degree_str | Master's |
| title | Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa |
| title_full | Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa |
| title_fullStr | Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa |
| title_full_unstemmed | Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa |
| title_short | Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa |
| title_sort | substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in south africa |
| url | http://hdl.handle.net/11427/11003 |
| work_keys_str_mv | AT kampiireleatitia substitutionstoinitialanteretroviraltherapyduetotoxicityorcontraindicationamongchildreninsouthafrica |