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Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
Includes bibliographical references (leaves 85-103).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Medical Microbiology
2015
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| _version_ | 1867613583967256576 |
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| access_status_str | Open Access |
| author | Salkinder, Amy Leia |
| author2 | Passmore, Jo-Ann |
| author_browse | Passmore, Jo-Ann Salkinder, Amy Leia |
| author_facet | Passmore, Jo-Ann Salkinder, Amy Leia |
| author_sort | Salkinder, Amy Leia |
| collection | Thesis |
| description | Includes bibliographical references (leaves 85-103). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11067 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:38:28.001Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Medical Microbiology |
| publisherStr | Division of Medical Microbiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11067 Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract Salkinder, Amy Leia Passmore, Jo-Ann Medical Microbiology Includes bibliographical references (leaves 85-103). T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to investigate the role of inflammatory/regulatory cytokines and bacterial burden in modulating Th17 cell frequencies in genital secretions and plasma. 2015-01-03T04:59:31Z 2015-01-03T04:59:31Z 2010 Master Thesis Masters MSc http://hdl.handle.net/11427/11067 eng application/pdf Division of Medical Microbiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Microbiology Salkinder, Amy Leia Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract |
| thesis_degree_str | Master's |
| title | Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract |
| title_full | Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract |
| title_fullStr | Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract |
| title_full_unstemmed | Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract |
| title_short | Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract |
| title_sort | impact of hiv infection on the frequency and phenotype of th17 cells in the female genital tract |
| topic | Medical Microbiology |
| url | http://hdl.handle.net/11427/11067 |
| work_keys_str_mv | AT salkinderamyleia impactofhivinfectiononthefrequencyandphenotypeofth17cellsinthefemalegenitaltract |