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The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease
Includes bibliographical references (p. 224-253).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Neurosurgery
2015
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| _version_ | 1867613241781256192 |
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| access_status_str | Open Access |
| author | Warton, Fleur L |
| author2 | Russell, Vivienne A |
| author_browse | Russell, Vivienne A Warton, Fleur L |
| author_facet | Russell, Vivienne A Warton, Fleur L |
| author_sort | Warton, Fleur L |
| collection | Thesis |
| description | Includes bibliographical references (p. 224-253). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11069 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:01.081Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Neurosurgery |
| publisherStr | Division of Neurosurgery |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11069 The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease Warton, Fleur L Russell, Vivienne A Includes bibliographical references (p. 224-253). Early developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. Given that stress has these behavioural effects, it is of interest to determine whether early developmental stress might enhance the toxicity of a later unrelated neural insult. The 6-hydroxydopamine (6-OHDA) model of Parkinson's disease involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA. 2015-01-03T05:23:55Z 2015-01-03T05:23:55Z 2010 Master Thesis Masters MSc http://hdl.handle.net/11427/11069 eng application/pdf Division of Neurosurgery Faculty of Health Sciences University of Cape Town |
| spellingShingle | Warton, Fleur L The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease |
| thesis_degree_str | Master's |
| title | The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease |
| title_full | The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease |
| title_fullStr | The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease |
| title_full_unstemmed | The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease |
| title_short | The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease |
| title_sort | effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of parkinson s disease |
| url | http://hdl.handle.net/11427/11069 |
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