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An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis
Includes bibliographical references (leaves 96-103).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Molecular and Cell Biology
2015
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| _version_ | 1867613207393206272 |
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| access_status_str | Open Access |
| author | Opap, Kenneth Babu |
| author2 | Mulder, Nicola |
| author_browse | Mulder, Nicola Opap, Kenneth Babu |
| author_facet | Mulder, Nicola Opap, Kenneth Babu |
| author_sort | Opap, Kenneth Babu |
| collection | Thesis |
| description | Includes bibliographical references (leaves 96-103). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11086 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:27.580Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11086 An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis Opap, Kenneth Babu Mulder, Nicola Cell Biology Includes bibliographical references (leaves 96-103). Proteins mediate bio-chemical processes in cellular organisms by functioning as structural components, signaling molecules, enzymes, transcription factors and receptors, through complex interactions that they make with one another. The study of protein-protein interactions (PPI) within an organism is thus a vital step towards understanding the cellular life process of an organism. PPIs have been studied by specially designed experiments to identify pairs of proteins that are suspected to interact. Experimental approaches are quite expensive, yet still there are cases of wrongly identified protein-protein interactions. In this study, we predict PPIs computationally by exploiting known properties of proteins and PPIs and the requirement that proteins be present in the same cell compartment at the same time in order to interact (subcellular localization and gene expression). 2015-01-03T05:29:18Z 2015-01-03T05:29:18Z 2011 Master Thesis Masters MSc http://hdl.handle.net/11427/11086 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Opap, Kenneth Babu An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis |
| thesis_degree_str | Master's |
| title | An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis |
| title_full | An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis |
| title_fullStr | An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis |
| title_full_unstemmed | An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis |
| title_short | An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis |
| title_sort | integrative approach to studying protein protein interactions within the genome of mycobacterium tuberculosis |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/11086 |
| work_keys_str_mv | AT opapkennethbabu anintegrativeapproachtostudyingproteinproteininteractionswithinthegenomeofmycobacteriumtuberculosis AT opapkennethbabu integrativeapproachtostudyingproteinproteininteractionswithinthegenomeofmycobacteriumtuberculosis |