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Cigarette smoke and human pulmonary immune responses to mycobacteria
Recent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on human cells that form part of the innate immune system of...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2015
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| _version_ | 1867613144263688192 |
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| access_status_str | Open Access |
| author | Van Zyl-Smit, Richard Nellis |
| author2 | Dheda, Keertan |
| author_browse | Dheda, Keertan Van Zyl-Smit, Richard Nellis |
| author_facet | Dheda, Keertan Van Zyl-Smit, Richard Nellis |
| author_sort | Van Zyl-Smit, Richard Nellis |
| collection | Thesis |
| description | Recent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on human cells that form part of the innate immune system of host defence in the lung. The experiments on the pulmonary effects of cigarette smoke confirm that exposure has a significant effect upon innate host defences. Significant reductions in the production of key cytokines implicated in defences against mycobacteria were observed, not attributable to impairment of mycobacterial uptake by cigarette smoke extract exposure. Furthermore, control of intracellular mycobacterial growth was impaired by cigarette smoke extract exposure. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11103 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:28.055Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11103 Cigarette smoke and human pulmonary immune responses to mycobacteria Van Zyl-Smit, Richard Nellis Dheda, Keertan Bateman, Eric D Medicine Recent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on human cells that form part of the innate immune system of host defence in the lung. The experiments on the pulmonary effects of cigarette smoke confirm that exposure has a significant effect upon innate host defences. Significant reductions in the production of key cytokines implicated in defences against mycobacteria were observed, not attributable to impairment of mycobacterial uptake by cigarette smoke extract exposure. Furthermore, control of intracellular mycobacterial growth was impaired by cigarette smoke extract exposure. 2015-01-03T05:36:35Z 2015-01-03T05:36:35Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11103 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Van Zyl-Smit, Richard Nellis Cigarette smoke and human pulmonary immune responses to mycobacteria |
| thesis_degree_str | Doctoral |
| title | Cigarette smoke and human pulmonary immune responses to mycobacteria |
| title_full | Cigarette smoke and human pulmonary immune responses to mycobacteria |
| title_fullStr | Cigarette smoke and human pulmonary immune responses to mycobacteria |
| title_full_unstemmed | Cigarette smoke and human pulmonary immune responses to mycobacteria |
| title_short | Cigarette smoke and human pulmonary immune responses to mycobacteria |
| title_sort | cigarette smoke and human pulmonary immune responses to mycobacteria |
| topic | Medicine |
| url | http://hdl.handle.net/11427/11103 |
| work_keys_str_mv | AT vanzylsmitrichardnellis cigarettesmokeandhumanpulmonaryimmuneresponsestomycobacteria |