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Social trauma and the mu-opioid system in depression
The overarching thesis under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate separation-distress, and that early social st...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Psychology
2015
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| _version_ | 1867613328670457856 |
|---|---|
| access_status_str | Open Access |
| author | Malcolm-Smith, Susan |
| author2 | Thomas, Kevin |
| author_browse | Malcolm-Smith, Susan Thomas, Kevin |
| author_facet | Thomas, Kevin Malcolm-Smith, Susan |
| author_sort | Malcolm-Smith, Susan |
| collection | Thesis |
| description | The overarching thesis under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate separation-distress, and that early social stressors lead to long term dysregulation in key related circuitries and neuroanatomical structures. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11123 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:23.309Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Psychology |
| publisherStr | Department of Psychology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11123 Social trauma and the mu-opioid system in depression Malcolm-Smith, Susan Thomas, Kevin Solms, Mark Psychology The overarching thesis under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate separation-distress, and that early social stressors lead to long term dysregulation in key related circuitries and neuroanatomical structures. 2015-01-03T05:39:34Z 2015-01-03T05:39:34Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11123 eng application/pdf Department of Psychology Faculty of Humanities University of Cape Town |
| spellingShingle | Psychology Malcolm-Smith, Susan Social trauma and the mu-opioid system in depression |
| thesis_degree_str | Doctoral |
| title | Social trauma and the mu-opioid system in depression |
| title_full | Social trauma and the mu-opioid system in depression |
| title_fullStr | Social trauma and the mu-opioid system in depression |
| title_full_unstemmed | Social trauma and the mu-opioid system in depression |
| title_short | Social trauma and the mu-opioid system in depression |
| title_sort | social trauma and the mu opioid system in depression |
| topic | Psychology |
| url | http://hdl.handle.net/11427/11123 |
| work_keys_str_mv | AT malcolmsmithsusan socialtraumaandthemuopioidsystemindepression |