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Studies on immunity in the male genital tract
The male genital tract is a major site of HIV acquisition and transmission. It is an obvious site for inducing immune responses to candidate HIV vaccines, to prevent infection or halt the spread of the virus. There are relatively few published studies characterising T cells in the male genital tract...
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| Format: | Thesis |
| Language: | English |
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Division of Virology
2015
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| _version_ | 1867613206595239936 |
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| access_status_str | Open Access |
| author | Olivier, Abraham Jacobus |
| author2 | Burgers, Wendy |
| author_browse | Burgers, Wendy Olivier, Abraham Jacobus |
| author_facet | Burgers, Wendy Olivier, Abraham Jacobus |
| author_sort | Olivier, Abraham Jacobus |
| collection | Thesis |
| description | The male genital tract is a major site of HIV acquisition and transmission. It is an obvious site for inducing immune responses to candidate HIV vaccines, to prevent infection or halt the spread of the virus. There are relatively few published studies characterising T cells in the male genital tract. A challenge that hampers studies at this mucosal surface is obtaining samples with sufficient immune cells. Therefore, the first aim of this study was to establish an optimised method to isolate immune cells from the male genital tract. Cellular activation and inflammation in the genital tract have important implications for both transmission and acquisition of HIV, since they provide target cells for viral replication. Thus, the second and third aim of this study was to investigate mucosal T cell activation and inflammatory cytokine profiles in semen in HIV?infected and uninfected men, and compare the immune milieu of the genital tract with the systemic compartment. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11234 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:27.580Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Virology |
| publisherStr | Division of Virology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11234 Studies on immunity in the male genital tract Olivier, Abraham Jacobus Burgers, Wendy Medical Virology The male genital tract is a major site of HIV acquisition and transmission. It is an obvious site for inducing immune responses to candidate HIV vaccines, to prevent infection or halt the spread of the virus. There are relatively few published studies characterising T cells in the male genital tract. A challenge that hampers studies at this mucosal surface is obtaining samples with sufficient immune cells. Therefore, the first aim of this study was to establish an optimised method to isolate immune cells from the male genital tract. Cellular activation and inflammation in the genital tract have important implications for both transmission and acquisition of HIV, since they provide target cells for viral replication. Thus, the second and third aim of this study was to investigate mucosal T cell activation and inflammatory cytokine profiles in semen in HIV?infected and uninfected men, and compare the immune milieu of the genital tract with the systemic compartment. 2015-01-04T14:20:37Z 2015-01-04T14:20:37Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11234 eng application/pdf Division of Virology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Virology Olivier, Abraham Jacobus Studies on immunity in the male genital tract |
| thesis_degree_str | Doctoral |
| title | Studies on immunity in the male genital tract |
| title_full | Studies on immunity in the male genital tract |
| title_fullStr | Studies on immunity in the male genital tract |
| title_full_unstemmed | Studies on immunity in the male genital tract |
| title_short | Studies on immunity in the male genital tract |
| title_sort | studies on immunity in the male genital tract |
| topic | Medical Virology |
| url | http://hdl.handle.net/11427/11234 |
| work_keys_str_mv | AT olivierabrahamjacobus studiesonimmunityinthemalegenitaltract |