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The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2015
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| _version_ | 1867613159346405376 |
|---|---|
| access_status_str | Open Access |
| author | Tukulula, Matshawandile |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Tukulula, Matshawandile |
| author_facet | Chibale, Kelly Tukulula, Matshawandile |
| author_sort | Tukulula, Matshawandile |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11310 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:43.046Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11310 The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents Tukulula, Matshawandile Chibale, Kelly Chemistry Includes bibliographical references. Malaria and tuberculosis are ancient diseases that continue to have a profound impact on mankind, 5 millennia after their first documentation. Malaria is endemic in more than 100 countries and about 50% of the world's population is at risk of infection. Sub-Saharan Africa accounts for nearly 91% of malaria-related deaths annually. Tuberculosis on the other hand infects about one third of the word's population and is the second major cause of death in adults worldwide, with about 1.8 million deaths reported annually. The major challenge to the control of these diseases has been the rapid emergence of multi-drug resistant strains to the currently administered drugs, as such, these exert an enormous pressure on health care systems, especially in resource-limited areas. Alleviation of this pressure requires the development of highly efficacious new chemical entities (NCEs) to curb or manage these pathogens. The main aim of this study was to design NCEs based on quinoline-, PA-824-, and tetrazole-scaffolds, which exhibit in vitro antiplasmodial and antimycobacterial activity. 2015-01-04T14:45:56Z 2015-01-04T14:45:56Z 2012 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11310 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Tukulula, Matshawandile The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents |
| thesis_degree_str | Doctoral |
| title | The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents |
| title_full | The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents |
| title_fullStr | The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents |
| title_full_unstemmed | The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents |
| title_short | The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents |
| title_sort | application of the multi component reaction mcr strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/11310 |
| work_keys_str_mv | AT tukululamatshawandile theapplicationofthemulticomponentreactionmcrstrategyinthedesignandsynthesisofnewantiplasmodialandantimycobacterialagents AT tukululamatshawandile applicationofthemulticomponentreactionmcrstrategyinthedesignandsynthesisofnewantiplasmodialandantimycobacterialagents |