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The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Anatomical Pathology
2015
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| _version_ | 1867613715026673664 |
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| access_status_str | Open Access |
| author | Wu, Hue-Tsi |
| author2 | Govender, Dhiren |
| author_browse | Govender, Dhiren Wu, Hue-Tsi |
| author_facet | Govender, Dhiren Wu, Hue-Tsi |
| author_sort | Wu, Hue-Tsi |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11479 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:40:32.989Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Anatomical Pathology |
| publisherStr | Division of Anatomical Pathology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11479 The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation Wu, Hue-Tsi Govender, Dhiren Anatomical Pathology Includes abstract. Includes bibliographical references. The WNT pathway is a major developmental pathway that plays an important role in the development of many tumours, including neuroectodermal and bone tumours. Ewing sarcoma (ES) / primitive neuroectodermal tumour (PNET) shows varying degrees of neuroectodermal differentiation and is the second commonest bone malignancy in childhood. A recent study on ES cell lines using RT-PCR analysis and biological response assays suggests that an intact WNT pathway exists in ES and that addition of exogenous WNT ligands enhances cell motility. Based on this we hypothesize that the WNT pathway may play a role in the biology of ES/PNET and we aim to investigate this by immunohistochemical stains on archival tissue. 2015-01-05T18:49:37Z 2015-01-05T18:49:37Z 2011 Master Thesis Masters MMed http://hdl.handle.net/11427/11479 eng application/pdf Division of Anatomical Pathology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Anatomical Pathology Wu, Hue-Tsi The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation |
| thesis_degree_str | Master's |
| title | The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation |
| title_full | The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation |
| title_fullStr | The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation |
| title_full_unstemmed | The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation |
| title_short | The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation |
| title_sort | wnt signalling pathway in ewing sarcoma primitive neuroectodermal tumour an immunohistochemical investigation |
| topic | Anatomical Pathology |
| url | http://hdl.handle.net/11427/11479 |
| work_keys_str_mv | AT wuhuetsi thewntsignallingpathwayinewingsarcomaprimitiveneuroectodermaltumouranimmunohistochemicalinvestigation AT wuhuetsi wntsignallingpathwayinewingsarcomaprimitiveneuroectodermaltumouranimmunohistochemicalinvestigation |