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Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Institute of Infectious Disease and Molecular Medicine
2015
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| _version_ | 1867613174378790912 |
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| access_status_str | Open Access |
| author | Mazandu, Gaston Kuzamunu |
| author2 | Mulder, Nicola |
| author_browse | Mazandu, Gaston Kuzamunu Mulder, Nicola |
| author_facet | Mulder, Nicola Mazandu, Gaston Kuzamunu |
| author_sort | Mazandu, Gaston Kuzamunu |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11590 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:56.645Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Institute of Infectious Disease and Molecular Medicine |
| publisherStr | Institute of Infectious Disease and Molecular Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11590 Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis Mazandu, Gaston Kuzamunu Mulder, Nicola Computational Biology Includes abstract. Includes bibliographical references (leaves 126-150). Mycobacterium tuberculosis is a bacterial pathogen that causes tuberculosis, a leading cause of human death worldwide from infectious diseases, especially in Africa. Despite enormous advances achieved in recent years in controlling the disease, tuberculosis remains a public health challenge. The contribution of existing drugs is of immense value, but the deadly synergy of the disease with Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS) and the emergence of drug resistant strains are threatening to compromise gains in tuberculosis control. In fact, the development of active tuberculosis is the outcome of the delicate balance between bacterial virulence and host resistance, which constitute two distinct and independent components. Significant progress has been made in understanding the evolution of the bacterial pathogen and its interaction with the host. The end point of these efforts is the identification of virulence factors and drug targets within the bacterium in order to develop new drugs and vaccines for the eradication of the disease. 2015-01-06T18:45:08Z 2015-01-06T18:45:08Z 2010 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11590 eng application/pdf Institute of Infectious Disease and Molecular Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Computational Biology Mazandu, Gaston Kuzamunu Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis |
| thesis_degree_str | Doctoral |
| title | Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis |
| title_full | Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis |
| title_fullStr | Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis |
| title_full_unstemmed | Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis |
| title_short | Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis |
| title_sort | data integration for the analysis of uncharacterized proteins in mycobacterium tuberculosis |
| topic | Computational Biology |
| url | http://hdl.handle.net/11427/11590 |
| work_keys_str_mv | AT mazandugastonkuzamunu dataintegrationfortheanalysisofuncharacterizedproteinsinmycobacteriumtuberculosis |