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Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2015
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| _version_ | 1867613244622897154 |
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| access_status_str | Open Access |
| author | Kambafwile, Henry Kunda |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Kambafwile, Henry Kunda |
| author_facet | Chibale, Kelly Kambafwile, Henry Kunda |
| author_sort | Kambafwile, Henry Kunda |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11736 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:04.194Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11736 Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group Kambafwile, Henry Kunda Chibale, Kelly Chemistry Includes bibliographical references. Angiotensin-converting enzyme (ACE) and P. falciparum A M1 (PfA-M1) are both zinc metalloproteases implicated in hypertension and malaria, respectively. Hypertension affects approximately 26 % of the world’s population while each year over 300 million cases of malaria occur worldwide resulting in between 1.5 and 2.7 million deaths annually. Hypertension treatment with current ACE inhibitors is marred by unpleasant side effects, such as cough and angioedema. In malaria, the parasites continuously develop resistance to anti-malarial drugs where the disease is endemic. There is therefore a need for continuous research into the application of new techniques as well as the design of new small molecule chemical entities as probes or chemotherapeutic agents. 2015-01-07T13:45:39Z 2015-01-07T13:45:39Z 2012 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11736 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Kambafwile, Henry Kunda Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group |
| thesis_degree_str | Doctoral |
| title | Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group |
| title_full | Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group |
| title_fullStr | Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group |
| title_full_unstemmed | Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group |
| title_short | Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group |
| title_sort | synthesis of activity based protein profiling probes for malaria and hypertension disease models potential novel ace inhibitors with an attenuated zinc binding group |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/11736 |
| work_keys_str_mv | AT kambafwilehenrykunda synthesisofactivitybasedproteinprofilingprobesformalariaandhypertensiondiseasemodelspotentialnovelaceinhibitorswithanattenuatedzincbindinggroup |