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Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2015
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| _version_ | 1867613283138142209 |
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| access_status_str | Open Access |
| author | Mugumbate, Grace Chitima |
| author2 | Jackson, Graham Ellis |
| author_browse | Jackson, Graham Ellis Mugumbate, Grace Chitima |
| author_facet | Jackson, Graham Ellis Mugumbate, Grace Chitima |
| author_sort | Mugumbate, Grace Chitima |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11737 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:40.116Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11737 Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae Mugumbate, Grace Chitima Jackson, Graham Ellis Chemistry Includes abstract. Includes bibliographical references (leaves 183-184). G-proton coupled receptors (GPCRs) are excellent drug targets that occupy a central position in the physiology of insects and are involved in transmission of signal from the extracellular to the intracellular side of the cell. Adipokinetic hormone receptors (AKHRs) are GPCRs that mediate physiological functions of the neurohormones, adipokinetic hormones (AKHs) that regulate mobilisation of energy reserves during mosquito flight. Ligand binding to GPCRs depends on the three dimensional (3D) structures of the receptors but to date no crystal structures of insect GPCRs are available. This work focused on building molecular models of AKHR from the genome of the malaria mosquito, identifying its binding site and studying the conformational and structural changes during molecular dynamics of the active and inactive receptor. 2015-01-07T13:45:46Z 2015-01-07T13:45:46Z 2010 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11737 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Mugumbate, Grace Chitima Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae |
| thesis_degree_str | Doctoral |
| title | Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae |
| title_full | Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae |
| title_fullStr | Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae |
| title_full_unstemmed | Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae |
| title_short | Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae |
| title_sort | enhancing the fight against malaria from genome to structure and activity of a g protein coupled receptor from the mosquito anopheles gambiae |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/11737 |
| work_keys_str_mv | AT mugumbategracechitima enhancingthefightagainstmalariafromgenometostructureandactivityofagproteincoupledreceptorfromthemosquitoanophelesgambiae |