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The molecular diagnosis of Pneumocystis pneumonia in children using nasopharyngeal aspirate samples

Pneumocystis pneumonia (PCP) is an important opportunistic infection caused by thefungus Pneumocystis jirovecii. The incidence of PCP in sub-Saharan Africa is on theincrease. This is due to the progression of the HIV-pandemic and limited access to healthcare facilities, specific highly active anti-r...

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Bibliographic Details
Main Author: Samuel, Catherine Mary
Other Authors: Whitelaw, Andrew
Format: Thesis
Language:English
Published: Division of Medical Microbiology 2015
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Summary:Pneumocystis pneumonia (PCP) is an important opportunistic infection caused by thefungus Pneumocystis jirovecii. The incidence of PCP in sub-Saharan Africa is on theincrease. This is due to the progression of the HIV-pandemic and limited access to healthcare facilities, specific highly active anti-retroviral therapy and chemoprophylaxis. It is a major cause of hospitalization and mortality in HIV-infected children with in-hospital case-fatality rates ranging from 20-63%.