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Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection
High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the transcription factor signal transducer and activator o...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Cardiology
2015
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| _version_ | 1867613184687341569 |
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| access_status_str | Open Access |
| author | Hacking, Damian |
| author2 | Lecour, Sandrine |
| author_browse | Hacking, Damian Lecour, Sandrine |
| author_facet | Lecour, Sandrine Hacking, Damian |
| author_sort | Hacking, Damian |
| collection | Thesis |
| description | High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the transcription factor signal transducer and activator of transcription 3 (STAT-3), has been identified as a key signalling pathway in cardioprotection, although the end effector remains unclear. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11755 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:07.214Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Cardiology |
| publisherStr | Division of Cardiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11755 Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection Hacking, Damian Lecour, Sandrine Cardiology High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the transcription factor signal transducer and activator of transcription 3 (STAT-3), has been identified as a key signalling pathway in cardioprotection, although the end effector remains unclear. 2015-01-08T19:48:32Z 2015-01-08T19:48:32Z 2011 Master Thesis Masters MMed http://hdl.handle.net/11427/11755 eng application/pdf Division of Cardiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Cardiology Hacking, Damian Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection |
| thesis_degree_str | Master's |
| title | Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection |
| title_full | Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection |
| title_fullStr | Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection |
| title_full_unstemmed | Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection |
| title_short | Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection |
| title_sort | role of the safe pathway and the mitochondria in hdl cholesterol and its constituent sphingosine 1 phosphate induced cardioprotection |
| topic | Cardiology |
| url | http://hdl.handle.net/11427/11755 |
| work_keys_str_mv | AT hackingdamian roleofthesafepathwayandthemitochondriainhdlcholesterolanditsconstituentsphingosine1phosphateinducedcardioprotection |