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Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2015
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| _version_ | 1867613320353153024 |
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| access_status_str | Open Access |
| author | Gumede, Dimakatso |
| author2 | Ojuka, Edward |
| author_browse | Gumede, Dimakatso Ojuka, Edward |
| author_facet | Ojuka, Edward Gumede, Dimakatso |
| author_sort | Gumede, Dimakatso |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11772 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:14.045Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11772 Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A Gumede, Dimakatso Ojuka, Edward Cell Biology Includes abstract. Includes bibliographical references. Previous studies have shown that over-expression of nuclear respiratory factor (NRF)-1 in mice increases glucose transporter (GLUT)-4 and myocyte enhancer factor (MEF-) 2A content, but the mechanisms have not been elucidated. Because NRF-1 has a binding site on the mef2a gene, and MEF2A binds the glut4 gene as a MEF2A-MEF2D heterodimer, the aims of this study were to determine whether NRF-1 over-expression a) enhanced GLUT4 expression indirectly via MEF2A and b) alters MEF2A-MEF2D dimer formation in C2C12 myotubes. 2015-01-08T19:56:31Z 2015-01-08T19:56:31Z 2012 Master Thesis Masters MSc http://hdl.handle.net/11427/11772 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Gumede, Dimakatso Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A |
| thesis_degree_str | Master's |
| title | Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A |
| title_full | Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A |
| title_fullStr | Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A |
| title_full_unstemmed | Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A |
| title_short | Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A |
| title_sort | over expression of nrf 1 in c2c12 myotubes increases glut4 content via a transcriptional cascade involving mef2a |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/11772 |
| work_keys_str_mv | AT gumededimakatso overexpressionofnrf1inc2c12myotubesincreasesglut4contentviaatranscriptionalcascadeinvolvingmef2a |