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The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry
2015
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| _version_ | 1867613145683460096 |
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| access_status_str | Open Access |
| author | Phillips, Pumza Samantha |
| author2 | Katz, Arieh |
| author_browse | Katz, Arieh Phillips, Pumza Samantha |
| author_facet | Katz, Arieh Phillips, Pumza Samantha |
| author_sort | Phillips, Pumza Samantha |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11787 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:30.019Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11787 The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation Phillips, Pumza Samantha Katz, Arieh Medical Biochemistry Includes abstract. Includes bibliographical references (leaves 72-78). The activation of Gonadotropin-releasing hormone receptor (GnRHR) by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive cancer cell lines. The GnRHR couples to Gαq in pituitary gonadotropes. However, the GnRHR expressed in reproductive cancer cell lines is thought to couple to Gαi. Recent evidence also suggests that the antiproliferative effects may be mediated via Gαq in these cells. Therefore our study involved determining the role of Gαi in the antiproliferative effects mediated by the GnRHR. The results suggest that the Gαi pathway could play a role in mediating the antiproliferative effects of GnRH. 2015-01-08T20:00:03Z 2015-01-08T20:00:03Z 2011 Master Thesis Masters MSc http://hdl.handle.net/11427/11787 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Phillips, Pumza Samantha The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation |
| thesis_degree_str | Master's |
| title | The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation |
| title_full | The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation |
| title_fullStr | The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation |
| title_full_unstemmed | The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation |
| title_short | The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation |
| title_sort | role of gai in the gonadotropin releasing hormone gnrh receptor inhibition of cell proliferation |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/11787 |
| work_keys_str_mv | AT phillipspumzasamantha theroleofgaiinthegonadotropinreleasinghormonegnrhreceptorinhibitionofcellproliferation AT phillipspumzasamantha roleofgaiinthegonadotropinreleasinghormonegnrhreceptorinhibitionofcellproliferation |