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Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models
The most common risk factors for chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) include chronic alcohol abuse and infection with hepatitis B (HBV) or hepatitis C (HCV) virus. Growing evidence from human studies and experimental models suggests that pre-degenerative and premalig...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Medicine
2015
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| _version_ | 1867614314926440448 |
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| access_status_str | Open Access |
| author | Setshedi, Mashiko |
| author2 | De la Monte, Suzanne M |
| author_browse | De la Monte, Suzanne M Setshedi, Mashiko |
| author_facet | De la Monte, Suzanne M Setshedi, Mashiko |
| author_sort | Setshedi, Mashiko |
| collection | Thesis |
| description | The most common risk factors for chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) include chronic alcohol abuse and infection with hepatitis B (HBV) or hepatitis C (HCV) virus. Growing evidence from human studies and experimental models suggests that pre-degenerative and premalignant abnormalities include disturbances in intracellular signaling and ongoing injury with oxidative stress, inflammation, and lipotoxicity. The major signal transduction pathways affected in both degenerative and neoplastic disease states in liver include: insulin/IGF, Wnt/β-catenin, and others. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11788 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:50:05.098Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11788 Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models Setshedi, Mashiko De la Monte, Suzanne M Internal Medicine The most common risk factors for chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) include chronic alcohol abuse and infection with hepatitis B (HBV) or hepatitis C (HCV) virus. Growing evidence from human studies and experimental models suggests that pre-degenerative and premalignant abnormalities include disturbances in intracellular signaling and ongoing injury with oxidative stress, inflammation, and lipotoxicity. The major signal transduction pathways affected in both degenerative and neoplastic disease states in liver include: insulin/IGF, Wnt/β-catenin, and others. 2015-01-08T20:00:30Z 2015-01-08T20:00:30Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11788 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Internal Medicine Setshedi, Mashiko Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models |
| thesis_degree_str | Doctoral |
| title | Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models |
| title_full | Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models |
| title_fullStr | Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models |
| title_full_unstemmed | Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models |
| title_short | Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models |
| title_sort | impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models |
| topic | Internal Medicine |
| url | http://hdl.handle.net/11427/11788 |
| work_keys_str_mv | AT setshedimashiko impairmentsinsignalingcascadesmediatingtheprogressionofliverdiseasefromchronichepatitistohepatocellularcarcinomainanimalandhumanmodels |