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Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Psychology
2015
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| _version_ | 1867613253716148225 |
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| access_status_str | Open Access |
| author | James, Katharine Ann |
| author2 | Thomas, Kevin |
| author_browse | James, Katharine Ann Thomas, Kevin |
| author_facet | Thomas, Kevin James, Katharine Ann |
| author_sort | James, Katharine Ann |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11796 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:12.104Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Psychology |
| publisherStr | Department of Psychology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11796 Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults James, Katharine Ann Thomas, Kevin Philosophy Includes bibliographical references. Many factors contribute to age-related changes in cognitive functioning. There is no single defined profile of factors that is clearly associated with the presence, or rate of progression, of cognitive changes in older adults. Stress, both psychosocial and physiological, may play a role. Aims: The general aim of this study was to explore the relationships between cognitive functioning and cognitive decline, on the one hand, and psychosocial and physiological stress, as well as a range of sociodemographic, psychosocial and physiological factors, on the other, in older adults with a range of cognitive function including healthy and impaired. Methods: Both cross-sectional (Study 1) and longitudinal (Study 2) designs addressed these aims. Study 1 examined the contribution of stress and sociodemographic, psychosocial, and physiological factors to cognition. Participants were 69 cognitively healthy older adults and 65 possible or probable Alzheimer’s disease (AD) patients. They were all over the age of 60 and resided in the greater Cape Town metropolitan region of South Africa. Cognitive functioning was assessed using a battery of neuropsychological tests. Salivary cortisol levels, apolipoprotein E (APOE) genotype, and plasma beta-amyloid levels were determined at baseline. 2015-01-08T20:02:22Z 2015-01-08T20:02:22Z 2013 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11796 eng application/pdf Department of Psychology Faculty of Humanities University of Cape Town |
| spellingShingle | Philosophy James, Katharine Ann Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults |
| thesis_degree_str | Doctoral |
| title | Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults |
| title_full | Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults |
| title_fullStr | Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults |
| title_full_unstemmed | Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults |
| title_short | Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults |
| title_sort | relationships between psychosocial stress cortisol apolipoprotein 1108 4 beta amyloid hippocampal volumes and alzheimer s disease in a sample of south african older adults |
| topic | Philosophy |
| url | http://hdl.handle.net/11427/11796 |
| work_keys_str_mv | AT jameskatharineann relationshipsbetweenpsychosocialstresscortisolapolipoprotein11084betaamyloidhippocampalvolumesandalzheimersdiseaseinasampleofsouthafricanolderadults |