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Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2015
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| _version_ | 1867613289717956608 |
|---|---|
| access_status_str | Open Access |
| author | Musonda, Chitalu Christopher |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Musonda, Chitalu Christopher |
| author_facet | Chibale, Kelly Musonda, Chitalu Christopher |
| author_sort | Musonda, Chitalu Christopher |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11811 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:45.686Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11811 Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents Musonda, Chitalu Christopher Chibale, Kelly Chemistry Includes bibliographical references. The work in this thesis is threefold: (i) A new series of antiplasmodial agents were initially designed based on the β-amino alcohol bioactiphore, a subunit that is found in a number of antimalarial agents. (ii) Various thiosemicarbozones and semicarbozones were designed and synthesized as potential mechanism-based inhibiotrs of parasitic cysteine proteases. (iii) Multicomponenet reactions offer the advantage of introducing chemical diversity in fewer steps than conventional multi step organic synthesis. New chloroquine-type compounds were designed and synthesized using the Ugi 4 component condensation reaction and its variants. The synthesized compounds ranged from simple peptidic molecules to rigid heterocycles. 2015-01-08T20:06:56Z 2015-01-08T20:06:56Z 2005 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11811 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Musonda, Chitalu Christopher Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents |
| thesis_degree_str | Doctoral |
| title | Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents |
| title_full | Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents |
| title_fullStr | Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents |
| title_full_unstemmed | Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents |
| title_short | Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents |
| title_sort | antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/11811 |
| work_keys_str_mv | AT musondachitaluchristopher antimalarialandcysteineproteaseinhibitorpharmacophoresasscaffoldsfornewantimalarialagents |