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Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2015
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| _version_ | 1867614026538680320 |
|---|---|
| access_status_str | Open Access |
| author | Swart, Marelize |
| author2 | Dandara, Collet |
| author_browse | Dandara, Collet Swart, Marelize |
| author_facet | Dandara, Collet Swart, Marelize |
| author_sort | Swart, Marelize |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11835 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:45:30.069Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11835 Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients Swart, Marelize Dandara, Collet Medicine Includes abstract. Includes bibliographical references (leaves 82-96). Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ABCB1. Genetic variability in the above genes may contribute to differences in EFV plasma concentrations which affect the levels of viral suppression as well as development of side effects in patients. The aim of this project was to evaluate the effects of the different genetic polymorphisms on EFV plasma concentration levels in HIV/AIDS patients receiving first-line antiretroviral treatment (ART) containing EFV. 2015-01-09T08:56:56Z 2015-01-09T08:56:56Z 2011 Master Thesis Masters MSc http://hdl.handle.net/11427/11835 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Swart, Marelize Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients |
| thesis_degree_str | Master's |
| title | Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients |
| title_full | Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients |
| title_fullStr | Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients |
| title_full_unstemmed | Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients |
| title_short | Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients |
| title_sort | pharmacogenetics of efavirenz response in bantu speaking south african hiv aids patients |
| topic | Medicine |
| url | http://hdl.handle.net/11427/11835 |
| work_keys_str_mv | AT swartmarelize pharmacogeneticsofefavirenzresponseinbantuspeakingsouthafricanhivaidspatients |