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The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Human Biology
2015
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| _version_ | 1867614191506948096 |
|---|---|
| access_status_str | Open Access |
| author | Davis, Emily |
| author2 | Prince, Sharon |
| author_browse | Davis, Emily Prince, Sharon |
| author_facet | Prince, Sharon Davis, Emily |
| author_sort | Davis, Emily |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11890 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:48:07.395Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11890 The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer Davis, Emily Prince, Sharon Human Biology Includes abstract. Includes bibliographical references (leaves 102-131). T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contributes to tumourigenesis. 2015-01-10T06:48:15Z 2015-01-10T06:48:15Z 2009 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11890 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Human Biology Davis, Emily The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer |
| thesis_degree_str | Doctoral |
| title | The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer |
| title_full | The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer |
| title_fullStr | The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer |
| title_full_unstemmed | The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer |
| title_short | The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer |
| title_sort | role of the developmentally important transcription factor tbx2 in the cell cycle and cancer |
| topic | Human Biology |
| url | http://hdl.handle.net/11427/11890 |
| work_keys_str_mv | AT davisemily theroleofthedevelopmentallyimportanttranscriptionfactortbx2inthecellcycleandcancer AT davisemily roleofthedevelopmentallyimportanttranscriptionfactortbx2inthecellcycleandcancer |