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Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines
Includes bibliographical references (leaves 129-146).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Molecular and Cell Biology
2015
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| _version_ | 1867613289726345217 |
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| access_status_str | Open Access |
| author | Burger, Marieta |
| author2 | Rybicki, Ed |
| author_browse | Burger, Marieta Rybicki, Ed |
| author_facet | Rybicki, Ed Burger, Marieta |
| author_sort | Burger, Marieta |
| collection | Thesis |
| description | Includes bibliographical references (leaves 129-146). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12377 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:45.686Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12377 Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines Burger, Marieta Rybicki, Ed Hitzeroth, Inga Molecular and Cell Biology Includes bibliographical references (leaves 129-146). Human papillomavirus (HPV) infection, specifically with oncogenic types, has been implicated in effectively all cervical cancer cases. Cervical cancer is a global health burden, especially in the developing world. Up to 18 types of HPV are considered oncogenic, of which HPV -16 and -18 cause 70% of cervical cancer cases worldwide. Two vaccines are available on the market: Gardasil(R), targeted against HPV -16, -18; -6 and -11, and Cervarix(TM), against -16 and -18. Both vaccines are based on the L1 capsid proteins of the types they are targeted to and are efficient, pro- phylactic, typespecific vaccines. However, two problems remain: they do not protect against nonvaccine types, that may cause a significant proportion of cancers specifically in African and HIV- positive populations, and they cannot be used to treat existing infections. We designed eight different chimaeric vaccines. 2015-02-04T19:14:50Z 2015-02-04T19:14:50Z 2010 Master Thesis Masters MSc http://hdl.handle.net/11427/12377 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Molecular and Cell Biology Burger, Marieta Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines |
| thesis_degree_str | Master's |
| title | Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines |
| title_full | Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines |
| title_fullStr | Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines |
| title_full_unstemmed | Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines |
| title_short | Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines |
| title_sort | production and immunogenicity of chimaeric human papillomavirus like particle vaccines |
| topic | Molecular and Cell Biology |
| url | http://hdl.handle.net/11427/12377 |
| work_keys_str_mv | AT burgermarieta productionandimmunogenicityofchimaerichumanpapillomaviruslikeparticlevaccines |