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Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes
Includes bibliographical references (leaves 69-72).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2015
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| _version_ | 1867613337432358912 |
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| access_status_str | Open Access |
| author | Muhunga, Denis Ngumbu |
| author2 | Gammon, David W |
| author_browse | Gammon, David W Muhunga, Denis Ngumbu |
| author_facet | Gammon, David W Muhunga, Denis Ngumbu |
| author_sort | Muhunga, Denis Ngumbu |
| collection | Thesis |
| description | Includes bibliographical references (leaves 69-72). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12396 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:32.198Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12396 Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes Muhunga, Denis Ngumbu Gammon, David W Chemistry Includes bibliographical references (leaves 69-72). Tuberculosis (TB) is one of the world's most deadly diseases and kills approximately 1.7 million people each year. The developing resistance of TB to the two most common anti-TB drugs (isoniazid and rifampicin) proves the urgency of the current situation. The MshB reducing agent exclusively in the actinomycetes is used as a model for the development of new anti-TB drugs. It was shown that the stereoselectivity synthesis of C-2 alkyl glucoside gave a key intermediate for the suitable synthesis of glycosyl donors. In addition, we achieved the preparation of D-inositol derivative chirally pure and having the hydroxyl at the 1-position. However, the attempted glycosylation reaction failed to give the desired product. 2015-02-06T11:28:20Z 2015-02-06T11:28:20Z 2010 Master Thesis Masters MSc http://hdl.handle.net/11427/12396 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Muhunga, Denis Ngumbu Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes |
| thesis_degree_str | Master's |
| title | Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes |
| title_full | Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes |
| title_fullStr | Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes |
| title_full_unstemmed | Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes |
| title_short | Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes |
| title_sort | stereoselective synthesis 2 c alkylglucosides potential inhibitors of mycobacterial mshb and related enzymes |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/12396 |
| work_keys_str_mv | AT muhungadenisngumbu stereoselectivesynthesis2calkylglucosidespotentialinhibitorsofmycobacterialmshbandrelatedenzymes |