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The role of the cytolytic mediators, granulysin and perforin, in tuberculosis
Includes bibliographical references (leaves 150-175).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Clinical Immunology
2015
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| _version_ | 1867613261572079616 |
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| access_status_str | Open Access |
| author | Semple, Patricia Lynn |
| author2 | Ress, Stanley |
| author_browse | Ress, Stanley Semple, Patricia Lynn |
| author_facet | Ress, Stanley Semple, Patricia Lynn |
| author_sort | Semple, Patricia Lynn |
| collection | Thesis |
| description | Includes bibliographical references (leaves 150-175). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12403 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:19.547Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Clinical Immunology |
| publisherStr | Division of Clinical Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12403 The role of the cytolytic mediators, granulysin and perforin, in tuberculosis Semple, Patricia Lynn Ress, Stanley Shephard, Enid Clinical Immunology Includes bibliographical references (leaves 150-175). Includes abstract. Protective immunity against mycobacterial infection requires an effective cytolytic response, in addition to an intact Type l (Th1) cytokine pathway. Natural killer (NK) cells and cytolytic T-cells (CTL) are essential components of protective immunity against tuberculosis (TB) and mediate granule-dependent killing of infected cells. Granulysin, an antimicrobial protein, and perforin, a pore-forming molecule, have been found to co-localise in the granules of these two cell types. Granulysin has been shown to be directly cytotoxic to extracellular Mycobacterium tuberculosis (M.tb) and, together with perforin, is cytolytic against intracellular mycobacteria. This project evaluated the role of these two cytolytic mediators in TB. 2015-02-10T13:27:27Z 2015-02-10T13:27:27Z 2008 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/12403 eng application/pdf Division of Clinical Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Clinical Immunology Semple, Patricia Lynn The role of the cytolytic mediators, granulysin and perforin, in tuberculosis |
| thesis_degree_str | Doctoral |
| title | The role of the cytolytic mediators, granulysin and perforin, in tuberculosis |
| title_full | The role of the cytolytic mediators, granulysin and perforin, in tuberculosis |
| title_fullStr | The role of the cytolytic mediators, granulysin and perforin, in tuberculosis |
| title_full_unstemmed | The role of the cytolytic mediators, granulysin and perforin, in tuberculosis |
| title_short | The role of the cytolytic mediators, granulysin and perforin, in tuberculosis |
| title_sort | role of the cytolytic mediators granulysin and perforin in tuberculosis |
| topic | Clinical Immunology |
| url | http://hdl.handle.net/11427/12403 |
| work_keys_str_mv | AT semplepatricialynn theroleofthecytolyticmediatorsgranulysinandperforinintuberculosis AT semplepatricialynn roleofthecytolyticmediatorsgranulysinandperforinintuberculosis |