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Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study
Bibliography: p. 181-184.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2015
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| _version_ | 1867613212322562050 |
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| access_status_str | Open Access |
| author | Koch, Klaus R |
| author2 | Fazakerley, G V |
| author_browse | Fazakerley, G V Koch, Klaus R |
| author_facet | Fazakerley, G V Koch, Klaus R |
| author_sort | Koch, Klaus R |
| collection | Thesis |
| description | Bibliography: p. 181-184. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12618 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:33.381Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12618 Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study Koch, Klaus R Fazakerley, G V Inorganic Chemistry Bibliography: p. 181-184. The aqueous solution conformation of SAH and SAM has been investigated using lanthanide probes. SAH at pH 7.0 interacts normally with lanthanide aquo ions and lanthanide-EDTA complexes via coordination at the carboxyl group. The conformation of the homocysteine fragment is found to, be extended but bent back towards the adenine base. SAM does not interact with lanthanide aquo ions in the pH region 2-7. It does form complexes with lanthanide-EDTA species via an ion-pairing mechanism rather than direct coordination. In addition to lanthanide probes, 250 MHz 1H n.m.r. spectra yielded vicinal JHH coupling constants from which the ribose conformation in both SAM and SAH could be more accurately determined. 2015-03-16T10:31:07Z 2015-03-16T10:31:07Z 1979 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/12618 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Inorganic Chemistry Koch, Klaus R Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study |
| thesis_degree_str | Doctoral |
| title | Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study |
| title_full | Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study |
| title_fullStr | Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study |
| title_full_unstemmed | Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study |
| title_short | Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study |
| title_sort | heavy metal interactions with nucleic acid derivatives a nuclear magnetic resonance study |
| topic | Inorganic Chemistry |
| url | http://hdl.handle.net/11427/12618 |
| work_keys_str_mv | AT kochklausr heavymetalinteractionswithnucleicacidderivativesanuclearmagneticresonancestudy |