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Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries
Introduction: Sphingosine 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus kinase/Signal...
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| Format: | Thesis |
| Language: | English |
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Division of Cardiology
2015
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| _version_ | 1867613231355265024 |
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| access_status_str | Open Access |
| author | King, Jonathan Chan |
| author2 | Lecour, Sandrine |
| author_browse | King, Jonathan Chan Lecour, Sandrine |
| author_facet | Lecour, Sandrine King, Jonathan Chan |
| author_sort | King, Jonathan Chan |
| collection | Thesis |
| description | Introduction: Sphingosine 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus kinase/Signal transducer and activator of transcription 3 (JAK/STAT-3) form part of a recently discovered powerful prosurvival path termed as the Survivor Activating Factor Enhancement (SAFE) pathway. The SAFE pathway plays a critical role in ischaemic preconditioning to promote cell survival but whether activation of STAT-3 is required for S1P preconditioning and ischaemic postconditioning induced cardioprotection is unknown. Hypothesis: Activation of the STAT-3 is required for S1P preconditioning and ischaemic postconditioning. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12692 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:51.499Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Cardiology |
| publisherStr | Division of Cardiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12692 Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries King, Jonathan Chan Lecour, Sandrine Opie, Lionel H Physiology Introduction: Sphingosine 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus kinase/Signal transducer and activator of transcription 3 (JAK/STAT-3) form part of a recently discovered powerful prosurvival path termed as the Survivor Activating Factor Enhancement (SAFE) pathway. The SAFE pathway plays a critical role in ischaemic preconditioning to promote cell survival but whether activation of STAT-3 is required for S1P preconditioning and ischaemic postconditioning induced cardioprotection is unknown. Hypothesis: Activation of the STAT-3 is required for S1P preconditioning and ischaemic postconditioning. 2015-04-22T12:52:05Z 2015-04-22T12:52:05Z 2011 Master Thesis Masters MMed http://hdl.handle.net/11427/12692 eng application/pdf Division of Cardiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Physiology King, Jonathan Chan Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries |
| thesis_degree_str | Master's |
| title | Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries |
| title_full | Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries |
| title_fullStr | Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries |
| title_full_unstemmed | Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries |
| title_short | Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries |
| title_sort | cardioprotective role of signal transducer activator of transcription 3 stat 3 against ischaemai reperfusion injuries |
| topic | Physiology |
| url | http://hdl.handle.net/11427/12692 |
| work_keys_str_mv | AT kingjonathanchan cardioprotectiveroleofsignaltransduceractivatoroftranscription3stat3againstischaemaireperfusioninjuries |