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Genetic risk factors for carpal tunnel syndrome
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Human Biology
2015
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| _version_ | 1867613181225992192 |
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| access_status_str | Open Access |
| author | Burger, Marilize Cornelle |
| author2 | Collins, Malcolm |
| author_browse | Burger, Marilize Cornelle Collins, Malcolm |
| author_facet | Collins, Malcolm Burger, Marilize Cornelle |
| author_sort | Burger, Marilize Cornelle |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12714 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:03.909Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12714 Genetic risk factors for carpal tunnel syndrome Burger, Marilize Cornelle Collins, Malcolm Includes bibliographical references. Carpal tunnel syndrome (CTS) is a common occupational injury that is caused by an increase in pressure within the carpal tunnel structure which, in turn, causes compression of the median nerve. Although several factors are believed to be associated with increased risk of CTS, the direct causes of this injury remain unknown and it is generally accepted that CTS, with the exception of acutely caused CTS, is a multifactorial condition. Although it is generally accepted that an increase in pressure within the carpal tunnel structure, which contains nine flexor tendons, causes compression of the median nerve, the involvement of these tendons and other connective tissue structures in the aetiology of CTS cannot be excluded. In support of this, pathology of these connective structures have been proposed as being comorbid conditions or a precursor of CTS, cause CTS and/or can lead to an increase in carpal tunnel pressure. Several studies have suggested that specific non-occupational risk factors, such as anatomical, systemic and chronic factors as well as mostly repetition- and force-related occupational risk factors are associated with CTS. Although genetic influences in the aetiology of CTS have been proposed, this area has received little attention. Common DNA sequence variants on the other hand have previously been reported to associate with common exercise-associated tendon, such as chronic Achilles tendinopathy, and ligament injuries. The aim of this thesis was to determine whether common DNA sequence variants within several genes that have been associated or implicated in the aetiology of exercise-related musculoskeletal soft tissue injuries, are associated with altered risk of CTS by using a genetic association case-control study approach. 2015-05-04T07:07:15Z 2015-05-04T07:07:15Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/12714 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Burger, Marilize Cornelle Genetic risk factors for carpal tunnel syndrome |
| thesis_degree_str | Doctoral |
| title | Genetic risk factors for carpal tunnel syndrome |
| title_full | Genetic risk factors for carpal tunnel syndrome |
| title_fullStr | Genetic risk factors for carpal tunnel syndrome |
| title_full_unstemmed | Genetic risk factors for carpal tunnel syndrome |
| title_short | Genetic risk factors for carpal tunnel syndrome |
| title_sort | genetic risk factors for carpal tunnel syndrome |
| url | http://hdl.handle.net/11427/12714 |
| work_keys_str_mv | AT burgermarilizecornelle geneticriskfactorsforcarpaltunnelsyndrome |