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An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
Includes abstract.~Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry
2015
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| _version_ | 1867614103200071680 |
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| access_status_str | Open Access |
| author | Smith, Muneerah |
| author2 | Parker, Iqbal |
| author_browse | Parker, Iqbal Smith, Muneerah |
| author_facet | Parker, Iqbal Smith, Muneerah |
| author_sort | Smith, Muneerah |
| collection | Thesis |
| description | Includes abstract.~Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12795 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:46:43.180Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12795 An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds Smith, Muneerah Parker, Iqbal Kaschula, Catherine Hart Medical Biochemistry Includes abstract.~Includes bibliographical references. Crushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal cancer cells. Structure-activity studies showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values. 2015-05-13T14:19:00Z 2015-05-13T14:19:00Z 2014 Master Thesis Masters MSc http://hdl.handle.net/11427/12795 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Smith, Muneerah An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds |
| thesis_degree_str | Master's |
| title | An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds |
| title_full | An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds |
| title_fullStr | An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds |
| title_full_unstemmed | An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds |
| title_short | An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds |
| title_sort | investigation into the anti cancer mechanism of garlic related organosulfur compounds |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/12795 |
| work_keys_str_mv | AT smithmuneerah aninvestigationintotheanticancermechanismofgarlicrelatedorganosulfurcompounds AT smithmuneerah investigationintotheanticancermechanismofgarlicrelatedorganosulfurcompounds |