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Investigation of local South African avipoxviruses as potential vaccine vectors
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Clinical Laboratory Sciences
2015
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| _version_ | 1867613181599285248 |
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| access_status_str | Open Access |
| author | Offerman, Kristy-Maree |
| author2 | Williamson, Anna-Lise |
| author_browse | Offerman, Kristy-Maree Williamson, Anna-Lise |
| author_facet | Williamson, Anna-Lise Offerman, Kristy-Maree |
| author_sort | Offerman, Kristy-Maree |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12869 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:03.909Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Clinical Laboratory Sciences |
| publisherStr | Department of Clinical Laboratory Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12869 Investigation of local South African avipoxviruses as potential vaccine vectors Offerman, Kristy-Maree Williamson, Anna-Lise Douglass, Nicola Medical Virology Includes bibliographical references. Avipoxviruses are large, genetically diverse DNA viruses which are particularly desirable for use as vaccine vectors as a result of their excellent safety profile and host range restriction. In this study, 8 novel South African (SA) avipoxvirus isolates were characterized. They could be divided into five groups, according to gross pathology and pock appearance on CAMs. Histopathology revealed distinct differences in epidermal and mesodermal cell proliferation, as well as immune cell infiltration, caused by the different avipoxviruses. Phylogenetic analysis was performed based on several conserved poxvirus genetic regions, corresponding to vaccinia virus (VACV) A3L (fpv167 locus, VACV P4b), G8R (fpv126 locus, VLTF-1), H3L (fpv140 locus, VACV H3L) and A11R–A12L (fpv175–176 locus). The SA isolates all grouped in clade A, either in subclade A2 or A3 of the genus Avipoxvirus, with branching patterns which differed according to the locus analysed. 2015-05-26T14:14:41Z 2015-05-26T14:14:41Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/12869 eng application/pdf Department of Clinical Laboratory Sciences Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Virology Offerman, Kristy-Maree Investigation of local South African avipoxviruses as potential vaccine vectors |
| thesis_degree_str | Doctoral |
| title | Investigation of local South African avipoxviruses as potential vaccine vectors |
| title_full | Investigation of local South African avipoxviruses as potential vaccine vectors |
| title_fullStr | Investigation of local South African avipoxviruses as potential vaccine vectors |
| title_full_unstemmed | Investigation of local South African avipoxviruses as potential vaccine vectors |
| title_short | Investigation of local South African avipoxviruses as potential vaccine vectors |
| title_sort | investigation of local south african avipoxviruses as potential vaccine vectors |
| topic | Medical Virology |
| url | http://hdl.handle.net/11427/12869 |
| work_keys_str_mv | AT offermankristymaree investigationoflocalsouthafricanavipoxvirusesaspotentialvaccinevectors |