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Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Human Biology
2015
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| _version_ | 1867613297019191296 |
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| access_status_str | Open Access |
| author | O’Connell, Kevin Sean |
| author2 | Collins, Malcolm |
| author_browse | Collins, Malcolm O’Connell, Kevin Sean |
| author_facet | Collins, Malcolm O’Connell, Kevin Sean |
| author_sort | O’Connell, Kevin Sean |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12960 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:54.099Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12960 Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes O’Connell, Kevin Sean Collins, Malcolm Posthumus, Michael Exercise Science Includes bibliographical references. Previous findings have suggested that functional variants within collagen encoding genes are associated with several musculoskeletal soft tissue injuries and other exercise-related phenotypes. Specifically variants within the functional COL5A1 3’- untranslated region (UTR) have previously been associated with (1) chronic Achilles tendinopathy, (2) Anterior Cruciate Ligament (ACL) ruptures in females, (3) endurance running performance and (4) range of motion (ROM). Since this gene encodes for an important structural component of the collagen fibril it has been hypothesised that variants within other collagen fibril encoding genes, such as COL3A1, COL6A1 and COL12A1, will also be associated with these and/or other musculoskeletal soft tissue injuries and exercise-related phenotypes. The COL5A1 rs12722 and COL12A1 rs970547 gene variants have been previously associated with risk of ACL ruptures in females [153;154] and/or chronic Achilles tendinopathy [131;181]. The first aim of this thesis was therefore to investigate the COL3A1 rs1800255 and COL6A1 rs35796750 gene variants as risk factors for these musculoskeletal soft tissue injuries. 2015-05-28T04:15:23Z 2015-05-28T04:15:23Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/12960 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Exercise Science O’Connell, Kevin Sean Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes |
| thesis_degree_str | Doctoral |
| title | Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes |
| title_full | Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes |
| title_fullStr | Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes |
| title_full_unstemmed | Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes |
| title_short | Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes |
| title_sort | investigation of selected collagen genes in exercise related musculoskeletal soft tissue phenotypes |
| topic | Exercise Science |
| url | http://hdl.handle.net/11427/12960 |
| work_keys_str_mv | AT oconnellkevinsean investigationofselectedcollagengenesinexerciserelatedmusculoskeletalsofttissuephenotypes |