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Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Human Biology
2015
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| _version_ | 1867613236193394688 |
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| access_status_str | Open Access |
| author | Popovic, Ana |
| author2 | Davids, Lester M |
| author_browse | Davids, Lester M Popovic, Ana |
| author_facet | Davids, Lester M Popovic, Ana |
| author_sort | Popovic, Ana |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13240 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:56.154Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13240 Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells Popovic, Ana Davids, Lester M Cell Biology Includes bibliographical references. Skin cancer is the most common cancer worldwide, and its incidence rate in South Africa is increasing. Photodynamic therapy (PDT) has been shown to be an effective treatment modality, through topical administration, for treatment of non-melanoma skin cancers. Our group investigates hypericin-induced PDT (HYP-PDT) for the treatment of both non-melanoma and melanoma skin cancers. However, a prerequisite for effective cancer treatments is efficient and selective targeting of the tumoral cells with minimal collateral damage to the surrounding normal cells, as it is well know that cancer therapies have bystander effects on normal cells in the body, often causing undesirable side effects. PDT can induce a bystander effect, defined as indirect damaged induced into adjacent cells either via intercellular gap junctions or via diffusible ROS released in the microenvironment. It is therefore important to know the effects of HYP-PDT on the normal cell population surrounding the non-melanoma skin cancer or melanoma tumor. The aim of this project was to investigate the cellular and molecular effects of HYP-PDT on normal primary human keratinocytes (Kc), melanocytes (Mc) and fibroblasts (Fb) in an in vitro tissue culture model thus representing both the epidermal and dermal cellular compartments of human skin. 2015-07-01T09:01:24Z 2015-07-01T09:01:24Z 2014 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/13240 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Cell Biology Popovic, Ana Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells |
| thesis_degree_str | Master's |
| title | Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells |
| title_full | Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells |
| title_fullStr | Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells |
| title_full_unstemmed | Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells |
| title_short | Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells |
| title_sort | investigating the by stander effect of hypericin induced photodynamic therapy on human skin cells |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/13240 |
| work_keys_str_mv | AT popovicana investigatingthebystandereffectofhypericininducedphotodynamictherapyonhumanskincells |