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In situ sintering study of model nickel catalysts
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemical Engineering
2015
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| _version_ | 1867613151946604544 |
|---|---|
| access_status_str | Open Access |
| author | Maphutha, Malebelo |
| author2 | Claeys, Michael |
| author_browse | Claeys, Michael Maphutha, Malebelo |
| author_facet | Claeys, Michael Maphutha, Malebelo |
| author_sort | Maphutha, Malebelo |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13326 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:35.974Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemical Engineering |
| publisherStr | Department of Chemical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13326 In situ sintering study of model nickel catalysts Maphutha, Malebelo Claeys, Michael Chemical Engineering Includes bibliographical references. Lipid catabolism plays a significant role in the survival of M.tb inside the host. The development of analytical techniques such as gas chromatography mass spectroscopy (GCMS) and liquid chromatography mass spectroscopy (LC-MS) has become popular as metabolomics tools in the study of such catabolic pathways. The development of biomarkers and internal standards to perform quantitative and qualitative analysis of metabolites in the catabolic pathway would be an attractive tool. Thus, cholesterol derivatives were synthesized as thia-, fluoro- and deuterium labeled analogs. Sulfur was incorporated into cholesterol at positions, C3 as well as C23. The 3â-mercaptocholest-5-ene was synthesized to block the initial stage of cholesterol catabolism and evaluate whether side chain degradation can still occur. Fluorine was integrated into the cholesterol backbone at C3 to evaluate the side-chain degradation in the absence of cholesterol oxidase activity. Steroids with fluorine at C6 are known to have good biological activity and were for this reason also synthesized. Deuterium labeled compounds were synthesized and used as internal standards for GC-MS analysis. As an alternative to cholesterol catabolism, fatty acids like stearic acid are important in producing building blocks for long chain mycolic acids which provides protection to the mycobacterium. For this reason thiastearic acid derivatives were synthesized and evaluated as biomarkers. 2015-07-03T08:27:25Z 2015-07-03T08:27:25Z 2014 Master Thesis Masters MSc (Eng) http://hdl.handle.net/11427/13326 eng application/pdf Department of Chemical Engineering Faculty of Engineering and the Built Environment University of Cape Town |
| spellingShingle | Chemical Engineering Maphutha, Malebelo In situ sintering study of model nickel catalysts |
| thesis_degree_str | Master's |
| title | In situ sintering study of model nickel catalysts |
| title_full | In situ sintering study of model nickel catalysts |
| title_fullStr | In situ sintering study of model nickel catalysts |
| title_full_unstemmed | In situ sintering study of model nickel catalysts |
| title_short | In situ sintering study of model nickel catalysts |
| title_sort | in situ sintering study of model nickel catalysts |
| topic | Chemical Engineering |
| url | http://hdl.handle.net/11427/13326 |
| work_keys_str_mv | AT maphuthamalebelo insitusinteringstudyofmodelnickelcatalysts |