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CD146 expression in early and late onset pre-eclampsia : is there a difference?
Includes bibliographical references.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Anatomical Pathology
2015
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| _version_ | 1867613307449376768 |
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| access_status_str | Open Access |
| author | Schubert, Pawel Tomasz |
| author2 | Wainwright, Helen |
| author_browse | Schubert, Pawel Tomasz Wainwright, Helen |
| author_facet | Wainwright, Helen Schubert, Pawel Tomasz |
| author_sort | Schubert, Pawel Tomasz |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13337 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:03.682Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Anatomical Pathology |
| publisherStr | Division of Anatomical Pathology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13337 CD146 expression in early and late onset pre-eclampsia : is there a difference? Schubert, Pawel Tomasz Wainwright, Helen Wright, Colleen A Paediatric Pathology Includes bibliographical references. Objective: To investigate the difference in expression of CD146 immunohistochemical staining on intermediate trophoblast in early and late onset pre-eclampsia placentas as well as comparing this expression to gestational age matched control placentas. Study Design: Retrospective case series of 100 placentas: 25 early onset and 25 late onset pre-eclampsia placentas as well as 25 early and 25 late gestational age matched control placentas. Placentas were obtained from patients delivering in Tygerberg Hospital. Methods: Placentas were routinely fixed and processed. 2 sections of one preselected block from each case was cut and stained with CD146 and MNF116 immunohistochemical stain. The expression of the staining would be performed by means of analytical and image analysing software. Results: The study failed to demonstrate differences in CD146 expression by the intermediate trophoblast in the pre-eclampsia and control placentas. The analytical approach was deemed to be subjective and the image analysing software had too much background staining and inaccurate identification of the intermediate trophoblast in order to produce reproducible consistent results. Conclusion: Dual staining, using immunofluorescent staining of CD146 and MNF116 on smaller biopsies of the decidua are thought to be able to produce much better material for image analyses software. 2015-07-03T08:29:09Z 2015-07-03T08:29:09Z 2014 Master Thesis Masters MPhil http://hdl.handle.net/11427/13337 eng application/pdf Division of Anatomical Pathology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Paediatric Pathology Schubert, Pawel Tomasz CD146 expression in early and late onset pre-eclampsia : is there a difference? |
| thesis_degree_str | Master's |
| title | CD146 expression in early and late onset pre-eclampsia : is there a difference? |
| title_full | CD146 expression in early and late onset pre-eclampsia : is there a difference? |
| title_fullStr | CD146 expression in early and late onset pre-eclampsia : is there a difference? |
| title_full_unstemmed | CD146 expression in early and late onset pre-eclampsia : is there a difference? |
| title_short | CD146 expression in early and late onset pre-eclampsia : is there a difference? |
| title_sort | cd146 expression in early and late onset pre eclampsia is there a difference |
| topic | Paediatric Pathology |
| url | http://hdl.handle.net/11427/13337 |
| work_keys_str_mv | AT schubertpaweltomasz cd146expressioninearlyandlateonsetpreeclampsiaisthereadifference |