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Outcomes of infants starting Antiretroviral therapy in Southern Africa
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Public Health and Family Medicine
2015
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| _version_ | 1867613216678346752 |
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| access_status_str | Open Access |
| author | Porter, Mireille |
| author2 | Davies, Mary-Ann |
| author_browse | Davies, Mary-Ann Porter, Mireille |
| author_facet | Davies, Mary-Ann Porter, Mireille |
| author_sort | Porter, Mireille |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13343 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:37.404Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13343 Outcomes of infants starting Antiretroviral therapy in Southern Africa Porter, Mireille Davies, Mary-Ann Eley, Brian Public Health Includes bibliographical references. Within the global burden of the Human Immune Deficiency Virus (HIV) stands a distinct group - HIV infected infants. They are a physically, physiologically, developmentally and socially vulnerable group who differ considerably from their adult and child HIV infected counterparts. Distinguished in part by their multiple age-specific complexities in testing, treatment and monitoring these infants ultimately experience accelerated disease progression and an increased risk of morbidity and mortality. Advances in evidence gained from trials of the benefits of early initiation of ART in infants have resulted in international treatment guidelines changes and an increase in velocity and coverage of infant ART provision. However, there is limited published data on the outcomes of infants starting ART in routine care in Southern Africa. Objectives: To describe the baseline characteristics of infants starting first line ART in routine care setting in Southern Africa. To describe and examine the outcomes of these infants including clinical, immunological and virological responses and to identify the determinants for these outcomes. Method: A retrospective analysis was performed of prospectively collected cohort data of infants that initiated ART in routine care settings at the International Epidemiologic Databases to Evaluate AIDS in Southern Africa (IeDEA-SA) collaborative sites. A description of demographic, clinical, laboratory and program baseline characteristics is provided and longitudinal profiles of response variables are described. The Kaplan-Meier method was used to assess time to outcomes of mortality and virological outcome. Cox Proportional Hazards models identified those baseline characteristics associated with each of these outcomes. Competing Risk Analysis provides Cumulative Incidence Functions for mortality and programmatic outcomes. Multiple imputation was conducted and Rubin’s Rules provided pooled estimates from Survival Analysis. 2015-07-03T08:30:26Z 2015-07-03T08:30:26Z 2014 Master Thesis Masters MPH http://hdl.handle.net/11427/13343 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Public Health Porter, Mireille Outcomes of infants starting Antiretroviral therapy in Southern Africa |
| thesis_degree_str | Master's |
| title | Outcomes of infants starting Antiretroviral therapy in Southern Africa |
| title_full | Outcomes of infants starting Antiretroviral therapy in Southern Africa |
| title_fullStr | Outcomes of infants starting Antiretroviral therapy in Southern Africa |
| title_full_unstemmed | Outcomes of infants starting Antiretroviral therapy in Southern Africa |
| title_short | Outcomes of infants starting Antiretroviral therapy in Southern Africa |
| title_sort | outcomes of infants starting antiretroviral therapy in southern africa |
| topic | Public Health |
| url | http://hdl.handle.net/11427/13343 |
| work_keys_str_mv | AT portermireille outcomesofinfantsstartingantiretroviraltherapyinsouthernafrica |