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New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments
Positron emission particle tracking (PEPT) is a non-invasive technique for studying the flow of particulate systems within industrial equipment. The technique tracks a tracer particle labelled with a positron emitting radionuclide moving within the field-of-view of a positron emission tomography (PE...
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| Format: | Thesis |
| Language: | English |
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Department of Chemical Engineering
2015
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| _version_ | 1867613208817172480 |
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| access_status_str | Open Access |
| author | Liu, Cong |
| author2 | Franzidis, Jean-Paul |
| author_browse | Franzidis, Jean-Paul Liu, Cong |
| author_facet | Franzidis, Jean-Paul Liu, Cong |
| author_sort | Liu, Cong |
| collection | Thesis |
| description | Positron emission particle tracking (PEPT) is a non-invasive technique for studying the flow of particulate systems within industrial equipment. The technique tracks a tracer particle labelled with a positron emitting radionuclide moving within the field-of-view of a positron emission tomography (PET) scanner. Two important components of the technique are a PET camera and PEPT tracers, which are particle tracers labelled with a positron emitting radionuclide. Currently, the majority of PEPT tracers are made with 68Ga or 18F. However, the relatively short half-life of these two radionuclides limits the application of PEPT to a maximum of 3 hours of experimental time. 64Cu is a potential candidate for PEPT tracer fabrication due to its relatively long half-life (12.7 h) which could extend the experimental running time of PEPT experiments to two uninterrupted days. The objective of the research described in this thesis was to develop a technique for radiolabelling tracers with 64Cu, and to test their efficacy in PEPT experiment. The work was conducted at Radionuclide Production Department, iThemba LABS near Cape Town, where high purity 64Cu was obtained by a two stages separation method using ion exchange chromatography. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13709 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:29.432Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemical Engineering |
| publisherStr | Department of Chemical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13709 New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments Liu, Cong Franzidis, Jean-Paul Buffler, Andy Cole, Katie Chemical Engineering Positron emission particle tracking (PEPT) is a non-invasive technique for studying the flow of particulate systems within industrial equipment. The technique tracks a tracer particle labelled with a positron emitting radionuclide moving within the field-of-view of a positron emission tomography (PET) scanner. Two important components of the technique are a PET camera and PEPT tracers, which are particle tracers labelled with a positron emitting radionuclide. Currently, the majority of PEPT tracers are made with 68Ga or 18F. However, the relatively short half-life of these two radionuclides limits the application of PEPT to a maximum of 3 hours of experimental time. 64Cu is a potential candidate for PEPT tracer fabrication due to its relatively long half-life (12.7 h) which could extend the experimental running time of PEPT experiments to two uninterrupted days. The objective of the research described in this thesis was to develop a technique for radiolabelling tracers with 64Cu, and to test their efficacy in PEPT experiment. The work was conducted at Radionuclide Production Department, iThemba LABS near Cape Town, where high purity 64Cu was obtained by a two stages separation method using ion exchange chromatography. 2015-08-12T04:04:24Z 2015-08-12T04:04:24Z 2015 Master Thesis Masters MSc (Eng) http://hdl.handle.net/11427/13709 eng application/pdf Department of Chemical Engineering Faculty of Engineering and the Built Environment University of Cape Town |
| spellingShingle | Chemical Engineering Liu, Cong New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments |
| thesis_degree_str | Master's |
| title | New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments |
| title_full | New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments |
| title_fullStr | New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments |
| title_full_unstemmed | New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments |
| title_short | New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments |
| title_sort | new technique for radiolabelling tracer with 64cu for positron emission particles tracking pept experiments |
| topic | Chemical Engineering |
| url | http://hdl.handle.net/11427/13709 |
| work_keys_str_mv | AT liucong newtechniqueforradiolabellingtracerwith64cuforpositronemissionparticlestrackingpeptexperiments |