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Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease
In the management of coronary artery disease (CAD) most advances have concerned improvements in catheter-based interventional techniques and complex pharmacotherapy, with an emphasis on time, which unfortunately, cannot always achieved. However, simple measures with reassuring benefit that can be pe...
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| Format: | Thesis |
| Language: | English |
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Division of Cardiology
2015
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| _version_ | 1867613146218233856 |
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| access_status_str | Open Access |
| author | Mothilal, Shikar |
| author2 | Opie, Lionel H |
| author_browse | Mothilal, Shikar Opie, Lionel H |
| author_facet | Opie, Lionel H Mothilal, Shikar |
| author_sort | Mothilal, Shikar |
| collection | Thesis |
| description | In the management of coronary artery disease (CAD) most advances have concerned improvements in catheter-based interventional techniques and complex pharmacotherapy, with an emphasis on time, which unfortunately, cannot always achieved. However, simple measures with reassuring benefit that can be performed even by non-cardiologists have been largely overlooked, or understated. These include limiting reperfusion injury by remote ischaemic conditioning (RIPC), a powerful protective mechanism that can be elicited by the transient occlusion of blood flow to a limb with a blood pressure cuff. More controversially, glucose-insulin-potassium (GIK) therapy in early ST elevation myocardial infarction (STEMI) has the potential to improve outcomes especially when timely restoration of vessel patency is difficult to achieve. This systematic review will evaluate the role of these therapies as adjuncts to revascularisation for treating coronary artery disease either electively or during an acute coronary syndrome. Objectives: To determine if RIPC or GIK therapy for CAD leads to reduced mortality (primary objective), infarct size, cardiac enzyme release or major adverse cardiac and cerebral events (MACCE) and to identify adverse effects associated with RIPC or GIK (secondary objectives). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13785 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:30.019Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Cardiology |
| publisherStr | Division of Cardiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13785 Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease Mothilal, Shikar Opie, Lionel H Engel, Mark E Medicine In the management of coronary artery disease (CAD) most advances have concerned improvements in catheter-based interventional techniques and complex pharmacotherapy, with an emphasis on time, which unfortunately, cannot always achieved. However, simple measures with reassuring benefit that can be performed even by non-cardiologists have been largely overlooked, or understated. These include limiting reperfusion injury by remote ischaemic conditioning (RIPC), a powerful protective mechanism that can be elicited by the transient occlusion of blood flow to a limb with a blood pressure cuff. More controversially, glucose-insulin-potassium (GIK) therapy in early ST elevation myocardial infarction (STEMI) has the potential to improve outcomes especially when timely restoration of vessel patency is difficult to achieve. This systematic review will evaluate the role of these therapies as adjuncts to revascularisation for treating coronary artery disease either electively or during an acute coronary syndrome. Objectives: To determine if RIPC or GIK therapy for CAD leads to reduced mortality (primary objective), infarct size, cardiac enzyme release or major adverse cardiac and cerebral events (MACCE) and to identify adverse effects associated with RIPC or GIK (secondary objectives). 2015-08-27T12:30:00Z 2015-08-27T12:30:00Z 2015 Master Thesis Masters MMed http://hdl.handle.net/11427/13785 eng application/pdf Division of Cardiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Mothilal, Shikar Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease |
| thesis_degree_str | Master's |
| title | Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease |
| title_full | Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease |
| title_fullStr | Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease |
| title_full_unstemmed | Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease |
| title_short | Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease |
| title_sort | time is muscle a systematic review investigating the role of remote ischaemic preconditioning and glucose insulin potassium infusions as adjunctive therapies to revascularisation in coronary artery disease |
| topic | Medicine |
| url | http://hdl.handle.net/11427/13785 |
| work_keys_str_mv | AT mothilalshikar timeismuscleasystematicreviewinvestigatingtheroleofremoteischaemicpreconditioningandglucoseinsulinpotassiuminfusionsasadjunctivetherapiestorevascularisationincoronaryarterydisease |