Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens
During the last decade, cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, p...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Clinical Laboratory Sciences
2015
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613302280945664 |
|---|---|
| access_status_str | Open Access |
| author | Vira, Alykhan |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Vira, Alykhan |
| author_facet | Brombacher, Frank Vira, Alykhan |
| author_sort | Vira, Alykhan |
| collection | Thesis |
| description | During the last decade, cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, particularly the α7 subtype on macrophages has potent anti-inflammatory effects. However, the role for muscarinic receptor has not yet been conclusively characterized. In this study, we demonstrate that M3 muscarinic receptor subtype is required for optimal protective immunity to two pathogens; the nematode Nippostrongylus brasiliensis and the bacterium Salmonella enterica sp. Tyhpimurium. M3R deficient mice (M3R-/-) were susceptible to infection with N.brasiliensis with decreased production of the protective cytokine IL-13. Furthermore, stimulation of lymphocytes with muscarinic agonists enhanced TH2 cytokine production in an M3R dependent manner. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13966 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:59.204Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Clinical Laboratory Sciences |
| publisherStr | Department of Clinical Laboratory Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13966 Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens Vira, Alykhan Brombacher, Frank Horsnell, William Immunology During the last decade, cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, particularly the α7 subtype on macrophages has potent anti-inflammatory effects. However, the role for muscarinic receptor has not yet been conclusively characterized. In this study, we demonstrate that M3 muscarinic receptor subtype is required for optimal protective immunity to two pathogens; the nematode Nippostrongylus brasiliensis and the bacterium Salmonella enterica sp. Tyhpimurium. M3R deficient mice (M3R-/-) were susceptible to infection with N.brasiliensis with decreased production of the protective cytokine IL-13. Furthermore, stimulation of lymphocytes with muscarinic agonists enhanced TH2 cytokine production in an M3R dependent manner. 2015-09-15T10:22:58Z 2015-09-15T10:22:58Z 2013 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/13966 eng application/pdf Department of Clinical Laboratory Sciences Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Vira, Alykhan Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens |
| thesis_degree_str | Doctoral |
| title | Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens |
| title_full | Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens |
| title_fullStr | Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens |
| title_full_unstemmed | Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens |
| title_short | Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens |
| title_sort | role of m3 muscarinic receptor in regulation of immunity to infectious pathogens |
| topic | Immunology |
| url | http://hdl.handle.net/11427/13966 |
| work_keys_str_mv | AT viraalykhan roleofm3muscarinicreceptorinregulationofimmunitytoinfectiouspathogens |