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Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity
Endothelial dysfunction is associated with cardiovascular disease risk factors and precedes structural changes in the blood vessels that occur prior to clinical manifestations. Measuring ethnic differences in microvascular endothelial function will provide insight into the disparate cardio-metabolic...
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| Format: | Thesis |
| Language: | English |
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Department of Human Biology
2015
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| _version_ | 1867613177018056704 |
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| access_status_str | Open Access |
| author | Pienaar, Paula Roxana |
| author2 | Lambert, Estelle V |
| author_browse | Lambert, Estelle V Pienaar, Paula Roxana |
| author_facet | Lambert, Estelle V Pienaar, Paula Roxana |
| author_sort | Pienaar, Paula Roxana |
| collection | Thesis |
| description | Endothelial dysfunction is associated with cardiovascular disease risk factors and precedes structural changes in the blood vessels that occur prior to clinical manifestations. Measuring ethnic differences in microvascular endothelial function will provide insight into the disparate cardio-metabolic disease profiles that exist within a multi-ethnic South African population. Moreover, it has been shown that insulin resistance is associated with microvascular endothelial dysfunction in obese persons4, but it is unclear whether this relationship is mediated by body fat in apparently healthy individuals with and without insulin resistance. To our knowledge this has not been done in a South African population. Aims: The overall aim of this thesis was to measure microvascular endothelial function using Laser Doppler Imagery (LDI) and iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) in a multi-ethnic, apparently healthy group to determine whether: 1) there are ethnic differences in microvascular endothelial function and 2) whether the association between microvascular endothelial function and insulin resistance (IR) is independent of body fat in women with and without IR. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13967 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:58.458Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13967 Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity Pienaar, Paula Roxana Lambert, Estelle V Micklesfield, Lisa K Exercise Science Endothelial dysfunction is associated with cardiovascular disease risk factors and precedes structural changes in the blood vessels that occur prior to clinical manifestations. Measuring ethnic differences in microvascular endothelial function will provide insight into the disparate cardio-metabolic disease profiles that exist within a multi-ethnic South African population. Moreover, it has been shown that insulin resistance is associated with microvascular endothelial dysfunction in obese persons4, but it is unclear whether this relationship is mediated by body fat in apparently healthy individuals with and without insulin resistance. To our knowledge this has not been done in a South African population. Aims: The overall aim of this thesis was to measure microvascular endothelial function using Laser Doppler Imagery (LDI) and iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) in a multi-ethnic, apparently healthy group to determine whether: 1) there are ethnic differences in microvascular endothelial function and 2) whether the association between microvascular endothelial function and insulin resistance (IR) is independent of body fat in women with and without IR. 2015-09-15T10:23:26Z 2015-09-15T10:23:26Z 2014 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/13967 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Exercise Science Pienaar, Paula Roxana Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity |
| thesis_degree_str | Master's |
| title | Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity |
| title_full | Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity |
| title_fullStr | Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity |
| title_full_unstemmed | Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity |
| title_short | Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity |
| title_sort | microvascular endothelial function in a multi ethnic group of apparently healthy south african men and women implications for testing and the relationship between insulin resistance and microvascular reactivity |
| topic | Exercise Science |
| url | http://hdl.handle.net/11427/13967 |
| work_keys_str_mv | AT pienaarpaularoxana microvascularendothelialfunctioninamultiethnicgroupofapparentlyhealthysouthafricanmenandwomenimplicationsfortestingandtherelationshipbetweeninsulinresistanceandmicrovascularreactivity |