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Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis
Includes bibliographical references (leaves 120-133).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Medical Microbiology
2015
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| _version_ | 1867613321214033920 |
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| access_status_str | Open Access |
| author | Williams, Monique J |
| author2 | Steyn, Lafras M |
| author_browse | Steyn, Lafras M Williams, Monique J |
| author_facet | Steyn, Lafras M Williams, Monique J |
| author_sort | Williams, Monique J |
| collection | Thesis |
| description | Includes bibliographical references (leaves 120-133). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/14800 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:14.045Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Medical Microbiology |
| publisherStr | Division of Medical Microbiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/14800 Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis Williams, Monique J Steyn, Lafras M Steenkamp, D J Medical Microbiology Includes bibliographical references (leaves 120-133). Ergothioneine and mycothiol are the two major low molecular weight thiols present in mycobacteria. The generation of mycothiol-deficient mutants has demonstrated its role in protecting M tuberculosis against oxidative and nitrosative stress. To date, no ergothioneine-deficient mutants have been identified and the role of ergothioneine in mycobacteria remains unknown. The work in this thesis was performed with the aim of better understanding the function of ergothioneine in mycobacteria, by studying its biosynthesis and the conditions affecting its production. 2015-11-10T14:14:48Z 2015-11-10T14:14:48Z 2007 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/14800 eng application/pdf Division of Medical Microbiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Microbiology Williams, Monique J Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis |
| thesis_degree_str | Doctoral |
| title | Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis |
| title_full | Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis |
| title_fullStr | Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis |
| title_full_unstemmed | Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis |
| title_short | Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis |
| title_sort | conditions affecting ergothioneine levels in mycobacterium smegmatis the attempted isolation of i n n n histidine methyltransferase the first enzyme in ergothioneine biosynthesis |
| topic | Medical Microbiology |
| url | http://hdl.handle.net/11427/14800 |
| work_keys_str_mv | AT williamsmoniquej conditionsaffectingergothioneinelevelsinmycobacteriumsmegmatistheattemptedisolationofinnnhistidinemethyltransferasethefirstenzymeinergothioneinebiosynthesis |