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High porosity electrospun scaffolds for small diameter vascular graft applications
Porosity, pore size and pore interconnectivity have been shown to be critical factors for cellular infiltration into vascular grafts. While electrospinning has been shown to produce many promising characteristics for the fabrication of vascular graft scaffolds, it has yet to create sufficient porosi...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Biomedical Engineering
2015
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| _version_ | 1867613286358319106 |
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| access_status_str | Open Access |
| author | Voorneveld, Jason Dirk |
| author2 | Bezuidenhout, Deon |
| author_browse | Bezuidenhout, Deon Voorneveld, Jason Dirk |
| author_facet | Bezuidenhout, Deon Voorneveld, Jason Dirk |
| author_sort | Voorneveld, Jason Dirk |
| collection | Thesis |
| description | Porosity, pore size and pore interconnectivity have been shown to be critical factors for cellular infiltration into vascular grafts. While electrospinning has been shown to produce many promising characteristics for the fabrication of vascular graft scaffolds, it has yet to create sufficient porosity for transmural endothelial in-growth. This study was aimed at using dual electrospinning with sacrificial fibre extraction to produce scaffolds with controllable porosity characteristics while maintaining sufficient structural strength to resist deformation during implantation. Scaffolds were subsequently covalently grafted with heparin, a known anti-coagulant with growth-factor binding properties. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/15762 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:43.673Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Biomedical Engineering |
| publisherStr | Division of Biomedical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/15762 High porosity electrospun scaffolds for small diameter vascular graft applications Voorneveld, Jason Dirk Bezuidenhout, Deon Bezuidenhout, Deon Franz, Thomas Biomedical Engineering Porosity, pore size and pore interconnectivity have been shown to be critical factors for cellular infiltration into vascular grafts. While electrospinning has been shown to produce many promising characteristics for the fabrication of vascular graft scaffolds, it has yet to create sufficient porosity for transmural endothelial in-growth. This study was aimed at using dual electrospinning with sacrificial fibre extraction to produce scaffolds with controllable porosity characteristics while maintaining sufficient structural strength to resist deformation during implantation. Scaffolds were subsequently covalently grafted with heparin, a known anti-coagulant with growth-factor binding properties. 2015-12-10T09:33:14Z 2015-12-10T09:33:14Z 2015 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/15762 eng application/pdf Division of Biomedical Engineering Faculty of Health Sciences University of Cape Town |
| spellingShingle | Biomedical Engineering Voorneveld, Jason Dirk High porosity electrospun scaffolds for small diameter vascular graft applications |
| thesis_degree_str | Master's |
| title | High porosity electrospun scaffolds for small diameter vascular graft applications |
| title_full | High porosity electrospun scaffolds for small diameter vascular graft applications |
| title_fullStr | High porosity electrospun scaffolds for small diameter vascular graft applications |
| title_full_unstemmed | High porosity electrospun scaffolds for small diameter vascular graft applications |
| title_short | High porosity electrospun scaffolds for small diameter vascular graft applications |
| title_sort | high porosity electrospun scaffolds for small diameter vascular graft applications |
| topic | Biomedical Engineering |
| url | http://hdl.handle.net/11427/15762 |
| work_keys_str_mv | AT voorneveldjasondirk highporosityelectrospunscaffoldsforsmalldiametervasculargraftapplications |