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Exploring the cardioprotective effect of synthetic wine in Long Evans rats
[No copyright notice] Background: Moderate and chronic consumption of red wine protects against cardiovascular disease. Wine is a complex matrix containing multiple molecules whose concentrations can vary from one bottle to another. Therefore, the delineation of the putative cardioprotective compone...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2015
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| _version_ | 1867613290931159040 |
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| access_status_str | Open Access |
| author | Dlamini, Lindizwe |
| author2 | Lecour, Sandrine |
| author_browse | Dlamini, Lindizwe Lecour, Sandrine |
| author_facet | Lecour, Sandrine Dlamini, Lindizwe |
| author_sort | Dlamini, Lindizwe |
| collection | Thesis |
| description | [No copyright notice] Background: Moderate and chronic consumption of red wine protects against cardiovascular disease. Wine is a complex matrix containing multiple molecules whose concentrations can vary from one bottle to another. Therefore, the delineation of the putative cardioprotective components in wine such as alcohol, resveratrol and melatonin is very challenging when using commercially available red wine. Aim: We aimed to use synthetic wine, whose composition is well characterized, to explore whether the presence of alcohol, resveratrol and melatonin (as found in commercial wines) contributes to the cardioprotective effect of chronic and moderate consumption of red wine (equivalent to 2 glasses of wine/day) in an animal model. Additionally, we hypothesized that synthetic wine enriched with resveratrol and melatonin confers cardioprotection via improvement of overall antioxidant profile. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/15763 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:48.261Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/15763 Exploring the cardioprotective effect of synthetic wine in Long Evans rats Dlamini, Lindizwe Lecour, Sandrine Blackurst, Dee Submitted for the Degree of Master of Science in Medicine [No copyright notice] Background: Moderate and chronic consumption of red wine protects against cardiovascular disease. Wine is a complex matrix containing multiple molecules whose concentrations can vary from one bottle to another. Therefore, the delineation of the putative cardioprotective components in wine such as alcohol, resveratrol and melatonin is very challenging when using commercially available red wine. Aim: We aimed to use synthetic wine, whose composition is well characterized, to explore whether the presence of alcohol, resveratrol and melatonin (as found in commercial wines) contributes to the cardioprotective effect of chronic and moderate consumption of red wine (equivalent to 2 glasses of wine/day) in an animal model. Additionally, we hypothesized that synthetic wine enriched with resveratrol and melatonin confers cardioprotection via improvement of overall antioxidant profile. 2015-12-10T09:33:39Z 2015-12-10T09:33:39Z 2015 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/15763 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Submitted for the Degree of Master of Science in Medicine Dlamini, Lindizwe Exploring the cardioprotective effect of synthetic wine in Long Evans rats |
| thesis_degree_str | Master's |
| title | Exploring the cardioprotective effect of synthetic wine in Long Evans rats |
| title_full | Exploring the cardioprotective effect of synthetic wine in Long Evans rats |
| title_fullStr | Exploring the cardioprotective effect of synthetic wine in Long Evans rats |
| title_full_unstemmed | Exploring the cardioprotective effect of synthetic wine in Long Evans rats |
| title_short | Exploring the cardioprotective effect of synthetic wine in Long Evans rats |
| title_sort | exploring the cardioprotective effect of synthetic wine in long evans rats |
| topic | Submitted for the Degree of Master of Science in Medicine |
| url | http://hdl.handle.net/11427/15763 |
| work_keys_str_mv | AT dlaminilindizwe exploringthecardioprotectiveeffectofsyntheticwineinlongevansrats |