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The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review
Includes bibliographical references
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Public Health and Family Medicine
2016
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| _version_ | 1867613197421248513 |
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| access_status_str | Open Access |
| author | Moloi, Annesinah |
| author2 | Engel, Mark E |
| author_browse | Engel, Mark E Moloi, Annesinah |
| author_facet | Engel, Mark E Moloi, Annesinah |
| author_sort | Moloi, Annesinah |
| collection | Thesis |
| description | Includes bibliographical references |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/16604 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:18.917Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/16604 The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review Moloi, Annesinah Engel, Mark E Abdullahi, Leila H Public Health Streptococcus Group A Streptococcus Carriage Carrier state Includes bibliographical references Asymptomatic children can be a major reservoir of pharyngeal Group A Streptococcus (GAS) with reported figures ranging from <10% to >20% in developing countries. There is a need to document GAS carriage in school children, which, together with the molecular characterisation (M-typing) of strains harboured in the pharynx of carriers, will help to ascertain the extent to which disease strains are prevalent amongst carriers. This background information would serve to assist healthcare providers in diagnosing symptomatic GAS pharyngitis, as well as could potentially contribute to the development of a GAS vaccine. Currently, data on GAS carriage prevalence and M-type distribution in African countries are largely scant. We therefore undertook to perform a systematic review to determine the prevalence and type distribution of asymptomatic streptococcus carriage in children aged 5 -15years, residing in African countries. Methods: We conducted a comprehensive literature search among a number of databases, using an African search filter to identify GAS prevalence studies that report on children between the ages of 5 - 15 years who reside in African countries. Electronic searches were complemented by a hand search performed on reference lists of potentially included studies. The search was not limited by year of publication and language. Two evaluators independently reviewed, rated, and abstracted data from each article. Prevalence estimates were pooled in a meta-analysis and stratified according to region and study design using Stata®. Specifically, we applied the random effects metaprop routine to aggregate prevalence estimates and account for between study variability in calculating the overall pooled estimates and 95% CI for GAS carriage prevalence. 2016-01-29T11:02:11Z 2016-01-29T11:02:11Z 2015 Master Thesis Masters MPH http://hdl.handle.net/11427/16604 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Public Health Streptococcus Group A Streptococcus Carriage Carrier state Moloi, Annesinah The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review |
| thesis_degree_str | Master's |
| title | The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review |
| title_full | The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review |
| title_fullStr | The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review |
| title_full_unstemmed | The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review |
| title_short | The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review |
| title_sort | prevalence of group a beta hemolytic streptococci carriage in children in africa a systematic review |
| topic | Public Health Streptococcus Group A Streptococcus Carriage Carrier state |
| url | http://hdl.handle.net/11427/16604 |
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