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The utility of CSF PCR in central nervous system Varicella zoster infection in HIV
Includes bibliographical references
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Urology
2016
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| _version_ | 1867613826147418112 |
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| access_status_str | Open Access |
| author | Stanley, Alan Michael |
| author2 | Bryer, Alan |
| author_browse | Bryer, Alan Stanley, Alan Michael |
| author_facet | Bryer, Alan Stanley, Alan Michael |
| author_sort | Stanley, Alan Michael |
| collection | Thesis |
| description | Includes bibliographical references |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/16778 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:42:18.962Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Division of Urology |
| publisherStr | Division of Urology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/16778 The utility of CSF PCR in central nervous system Varicella zoster infection in HIV Stanley, Alan Michael Bryer, Alan Bateman, Kathleen Neurology HIV Infections Meningitis Tuberculosis Includes bibliographical references Aims: To assess the clinical and cerebrospinal fluid characteristics, and the role of tuberculous meningitis (TBM) as a confounder, in a cohort of HIV positive individuals with positive varicella zoster virus (VZV) positive cerebrospinal fluid PCR. Methods: Patients in the NHLS database at Groote Schuur Hospital with positive CSF VZV PCR who were also HIV co-infected and whose folders were available for clinical review were reviewed. Clinical and biochemical data were collected. Patients were divided into two groups based an accepted case definition for TBM. Differences between groups were assessed using Mann-Whitney U or Chi squared tests as appropriate. Results: There were 437 for VZV PCR over three years. Of these 98 were positive and, after exclusions, 31 HIV positive patients were included for further analysis. Median age was 31 and median CD4 count was 146 cells/mm³. 11 (35%) had meningitis and 8 (25%) had encephalitis. 13 (42%) met the case definition for TBM. Patients with CNS varicella were frequently confused whereas those with TBM presented sub-acutely. There were no differences in CSF characteristics. Additional organisms were detected 6 (19%) patients. 4 (13%) patients died in hospital. CSF TB culture was requested in 24 (77%) patients and extra CNS samples were sent in only 4 patients. Conclusion: The clinical and CSF presentation of CNS Varicella and TBM overlap and in this cohort patients were under investigated for TB. In settings of high TB prevalence the possibility of false positive PCR or incidental varicella reactivation should be considered. 2016-02-05T07:19:18Z 2016-02-05T07:19:18Z 2015 Master Thesis Masters MMed http://hdl.handle.net/11427/16778 eng application/pdf Division of Urology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Neurology HIV Infections Meningitis Tuberculosis Stanley, Alan Michael The utility of CSF PCR in central nervous system Varicella zoster infection in HIV |
| thesis_degree_str | Master's |
| title | The utility of CSF PCR in central nervous system Varicella zoster infection in HIV |
| title_full | The utility of CSF PCR in central nervous system Varicella zoster infection in HIV |
| title_fullStr | The utility of CSF PCR in central nervous system Varicella zoster infection in HIV |
| title_full_unstemmed | The utility of CSF PCR in central nervous system Varicella zoster infection in HIV |
| title_short | The utility of CSF PCR in central nervous system Varicella zoster infection in HIV |
| title_sort | utility of csf pcr in central nervous system varicella zoster infection in hiv |
| topic | Neurology HIV Infections Meningitis Tuberculosis |
| url | http://hdl.handle.net/11427/16778 |
| work_keys_str_mv | AT stanleyalanmichael theutilityofcsfpcrincentralnervoussystemvaricellazosterinfectioninhiv AT stanleyalanmichael utilityofcsfpcrincentralnervoussystemvaricellazosterinfectioninhiv |