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An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape
Includes bibliographical references
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Public Health and Family Medicine
2016
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| _version_ | 1867613170292490240 |
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| access_status_str | Open Access |
| author | Reed, Robert Anthony |
| author2 | Coetzee, David |
| author_browse | Coetzee, David Reed, Robert Anthony |
| author_facet | Coetzee, David Reed, Robert Anthony |
| author_sort | Reed, Robert Anthony |
| collection | Thesis |
| description | Includes bibliographical references |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/16864 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:53.390Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/16864 An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape Reed, Robert Anthony Coetzee, David Public Health HIV Infections Children Includes bibliographical references Objective: To establish whether there is an association between HIV exposure and infectious disease mortality in children admitted to hospital in the Western Cape. Also to identify additional risk factors associated with mortality and the prevalence of HIV exposure. Methods: A case-control design was used to compare the HIV exposure status of 93 cases admitted with an infectious disease who died with 93 controls admitted with an infectious disease who did not die. Clinical and demographic data were collected via record review at three hospitals in the Western Cape . Factors associated with mortality were identified through regression analysis. Findings: 38.71% (36/93) of cases were HIV exposed versus 22.58% (21/93) of controls (p=0.017). 32.36% (30/93) of cases were HIV exposed uninfected (HEU) versus 18.28% (17/93) of controls (p=0.06). Being HEU was a risk factor for mortality after adjusting for age, sex, feeding practice, and main infection. The odds of death in HEU children was 2.29 times greater than in HUU (aOR: 2.29, 95% CI: 1.06-5.0). Age, sex, and feeding practice confounded the association between HIV exposure-infection and mortality. LRTI, septicaemia, and meningitis were all significantly associated with mortality at the 5% level. Children admitted with septicaemia demonstrated a 13.44 times increased odds of death (aOR: 13.44, 95% CI: 3.35-53.99). Conclusion: Children born to HIV positive mothers should be considered a vulnerable group even if vertical transmission has been prevented. Determination of exposure status could be a valuable tool for identifying children at increased risk of death. Septicaemia and meningitis also present a challenge in critical care in our sample. 2016-02-08T07:20:11Z 2016-02-08T07:20:11Z 2015 Master Thesis Masters MPH http://hdl.handle.net/11427/16864 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Public Health HIV Infections Children Reed, Robert Anthony An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape |
| thesis_degree_str | Master's |
| title | An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape |
| title_full | An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape |
| title_fullStr | An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape |
| title_full_unstemmed | An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape |
| title_short | An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape |
| title_sort | investigation into the role of hiv exposure status in infectious disease mortality in children in western cape |
| topic | Public Health HIV Infections Children |
| url | http://hdl.handle.net/11427/16864 |
| work_keys_str_mv | AT reedrobertanthony aninvestigationintotheroleofhivexposurestatusininfectiousdiseasemortalityinchildreninwesterncape AT reedrobertanthony investigationintotheroleofhivexposurestatusininfectiousdiseasemortalityinchildreninwesterncape |