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Statistical aspects of bioavailability
Includes bibliography.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Statistical Sciences
2016
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| _version_ | 1867613328231104512 |
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| access_status_str | Open Access |
| author | Fresen, John Lawrence |
| author2 | Juritz, June M |
| author_browse | Fresen, John Lawrence Juritz, June M |
| author_facet | Juritz, June M Fresen, John Lawrence |
| author_sort | Fresen, John Lawrence |
| collection | Thesis |
| description | Includes bibliography. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/17004 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:23.309Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Statistical Sciences |
| publisherStr | Department of Statistical Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/17004 Statistical aspects of bioavailability Fresen, John Lawrence Juritz, June M Mathematical Statistics Includes bibliography. In 1984 it became legal for pharmacists to offer customers a cheaper generic alternative for a given prescription. The motivation for this was the excessively high cost of brand name drugs. The substitution of a generic alternative for a brand name drug is based on the assumption that drugs with a comparable chemical composition will have a similar therapeutic effect. The fact that this supposition is not always true has been demonstrated by a number of particular drugs, digoxon being perhaps the most vivid example. The objective of this thesis is to review the statistical aspects associated with (i) measuring the bioavailability of a drug (Chapter 2) (ii) establishing the equivalence of a new and standard formulation of a drug (Chapter 3). In the process of reviewing the literature two problems were identified. Firstly, it is commonly assumed that bioavailability parameters follow either the normal or lognormal distribution. This assumption is difficult to defend, hence procedures based on such assumptions became suspect. Secondly, bioavailability is inherently multivariate whereas in practice univariate procedures are employed. Efren's bootstrap method, which does not rest on assumptions about the underlying distribution, is proposed as a tool for assessing bioequivalence. A new measure of bioequivalence, the Index of Concordance, is proposed. This index can be computed with equal ease for univariate or multivariate data using the bootstrap (Chapter 5). The bootstrap idea of resampling the data can also be applied to compartmental modelling of bioavailability data. One result of this is a nonparametric estimate of the underlying distribution of the bioavailability parameters (Chapter 6). The bootstrap is, on its own, a fascinating concept. A review of the bootstrap is given in Chapter 4. 2016-02-15T07:07:42Z 2016-02-15T07:07:42Z 1985 Master Thesis Masters MSc http://hdl.handle.net/11427/17004 eng application/pdf Department of Statistical Sciences Faculty of Science University of Cape Town |
| spellingShingle | Mathematical Statistics Fresen, John Lawrence Statistical aspects of bioavailability |
| thesis_degree_str | Master's |
| title | Statistical aspects of bioavailability |
| title_full | Statistical aspects of bioavailability |
| title_fullStr | Statistical aspects of bioavailability |
| title_full_unstemmed | Statistical aspects of bioavailability |
| title_short | Statistical aspects of bioavailability |
| title_sort | statistical aspects of bioavailability |
| topic | Mathematical Statistics |
| url | http://hdl.handle.net/11427/17004 |
| work_keys_str_mv | AT fresenjohnlawrence statisticalaspectsofbioavailability |