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Non-selective, calcium-permeable channels in the apical membrane of rabbit renal tubules and in the basolateral membrane of human renal tubules : an exploratory patch clamp study
Includes bibliography.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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MRC/UCT RU for Exercise and Sport Medicine
2016
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| _version_ | 1867613254885310464 |
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| access_status_str | Open Access |
| author | Saunders, James |
| author2 | Isaacson, Leon |
| author_browse | Isaacson, Leon Saunders, James |
| author_facet | Isaacson, Leon Saunders, James |
| author_sort | Saunders, James |
| collection | Thesis |
| description | Includes bibliography. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/17308 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:13.838Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | MRC/UCT RU for Exercise and Sport Medicine |
| publisherStr | MRC/UCT RU for Exercise and Sport Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/17308 Non-selective, calcium-permeable channels in the apical membrane of rabbit renal tubules and in the basolateral membrane of human renal tubules : an exploratory patch clamp study Saunders, James Isaacson, Leon Physiology Includes bibliography. The presence of calcium (Ca) channels has been investigated in the apical membrane of various segments of rabbit renal tubules and in the basolateral membrane of human tubules, using the patch clamp technique. The rabbit tubule segments comprised proximal straight tubules (PST), thick ascending limbs (TAL), distal convoluted tubules (OCT), and cortical collecting ducts (CCD). The human tubule segments could not be identified, but were probably of proximal origin. The luminal surfaces of the individual tubule segments were accessed by perfusing the tubule and inserting the patch pipette through the open end or, more frequently, by tearing open the tubule to allow direct access by a patch electrode. Either Ba (90 mM) or Ca (70 mM) was used in the pipettes. Where possible, channel activity was sought in voltage clamped (30 to -60 m V) excised patches. The data were digitized at l kHz, and filtered (200- 500 Hz) by a six-pole Bessel filter. 2016-02-29T11:55:35Z 2016-02-29T11:55:35Z 1992 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/17308 eng application/pdf MRC/UCT RU for Exercise and Sport Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Physiology Saunders, James Non-selective, calcium-permeable channels in the apical membrane of rabbit renal tubules and in the basolateral membrane of human renal tubules : an exploratory patch clamp study |
| thesis_degree_str | Doctoral |
| title | Non-selective, calcium-permeable channels in the apical membrane of rabbit renal tubules and in the basolateral membrane of human renal tubules : an exploratory patch clamp study |
| title_full | Non-selective, calcium-permeable channels in the apical membrane of rabbit renal tubules and in the basolateral membrane of human renal tubules : an exploratory patch clamp study |
| title_fullStr | Non-selective, calcium-permeable channels in the apical membrane of rabbit renal tubules and in the basolateral membrane of human renal tubules : an exploratory patch clamp study |
| title_full_unstemmed | Non-selective, calcium-permeable channels in the apical membrane of rabbit renal tubules and in the basolateral membrane of human renal tubules : an exploratory patch clamp study |
| title_short | Non-selective, calcium-permeable channels in the apical membrane of rabbit renal tubules and in the basolateral membrane of human renal tubules : an exploratory patch clamp study |
| title_sort | non selective calcium permeable channels in the apical membrane of rabbit renal tubules and in the basolateral membrane of human renal tubules an exploratory patch clamp study |
| topic | Physiology |
| url | http://hdl.handle.net/11427/17308 |
| work_keys_str_mv | AT saundersjames nonselectivecalciumpermeablechannelsintheapicalmembraneofrabbitrenaltubulesandinthebasolateralmembraneofhumanrenaltubulesanexploratorypatchclampstudy |