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Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction
Includes bibliographical references
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Clinical Laboratory Sciences
2016
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| _version_ | 1867613210899644416 |
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| access_status_str | Open Access |
| author | Patel, Satishkumar Ishverlal |
| author2 | Sewell, Trevor |
| author_browse | Patel, Satishkumar Ishverlal Sewell, Trevor |
| author_facet | Sewell, Trevor Patel, Satishkumar Ishverlal |
| author_sort | Patel, Satishkumar Ishverlal |
| collection | Thesis |
| description | Includes bibliographical references |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/17429 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:31.718Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Clinical Laboratory Sciences |
| publisherStr | Department of Clinical Laboratory Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/17429 Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction Patel, Satishkumar Ishverlal Sewell, Trevor Malaria Plasmodium falciparum Includes bibliographical references [No subject] Malaria infection caused by the apicomplexa pathogen Plasmodium falciparum has a high rate of resistance to existing anti-malarial drugs. The World Health Organisation recommended interventions are unlikely to eliminate the growth of resistance and it would therefore be prudent to continue the search for new drug targets for the continued combatting of malaria. Plasmodium falciparum is parasitic on the host for its metabolites and therefore inhibiting the transportation of glutamine from the host, has long been considered a potential strategy for combating the spread of infection. The recently sequenced Plasmodium falciparum genome has however shown that pathways for independent survival are also conserved. Therefore, combating the spread of Plasmodium falciparum in the human host, in addition to inhibiting the transportation of glutamine, will also require the inhibition of the de novo expression of essential amino acids within the Plasmodium falciparum cell. This could be achieved by inhibiting the glutamine synthetase gene, which is an essential step in the tri-carboxylic acid cycle. 2016-03-03T14:46:28Z 2016-03-03T14:46:28Z 2015 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/17429 eng application/pdf Department of Clinical Laboratory Sciences Faculty of Health Sciences University of Cape Town |
| spellingShingle | Malaria Plasmodium falciparum Patel, Satishkumar Ishverlal Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction |
| thesis_degree_str | Master's |
| title | Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction |
| title_full | Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction |
| title_fullStr | Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction |
| title_full_unstemmed | Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction |
| title_short | Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction |
| title_sort | soluble expression of plasmodium falciparum glutamine synthetase and three dimensional structure by single particle reconstruction |
| topic | Malaria Plasmodium falciparum |
| url | http://hdl.handle.net/11427/17429 |
| work_keys_str_mv | AT patelsatishkumarishverlal solubleexpressionofplasmodiumfalciparumglutaminesynthetaseandthreedimensionalstructurebysingleparticlereconstruction |