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The crystal and molecular structures of some transition metal-barbiturate complexes
This thesis describes the synthesis and X-ray structural investigation of four complexes of the type M(II)(barb)₂L₂ where M is a transition metal, barb is the anion of a substituted barbituric acid and L is an organic base. These compounds are of importance in the clinical detection and identificati...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2016
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| _version_ | 1867613215131697152 |
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| access_status_str | Open Access |
| author | Rodgers, Allen Lawrence |
| author2 | Nassimbeni, Luigi R |
| author_browse | Nassimbeni, Luigi R Rodgers, Allen Lawrence |
| author_facet | Nassimbeni, Luigi R Rodgers, Allen Lawrence |
| author_sort | Rodgers, Allen Lawrence |
| collection | Thesis |
| description | This thesis describes the synthesis and X-ray structural investigation of four complexes of the type M(II)(barb)₂L₂ where M is a transition metal, barb is the anion of a substituted barbituric acid and L is an organic base. These compounds are of importance in the clinical detection and identification of barbiturate drugs and this aspect is discussed in a later section. An infrared study of these compounds is also described. The individual components of the complexes, viz. the transition metals and the barbiturate ligands are in themselves of great biological and physiological significance. Although the human body is but 3% metals, life depends upon these elements far more than this figure suggests. For example, the transition series metals, even though some are present in only trace amounts, generally appear in the active centres of enzymes that catalyze substrates to form aggregate molecules. The barbiturates on the other hand are members of a group of widely used drugs known as hypnotics, many of which are medicinally applied today. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/17788 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:36.207Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/17788 The crystal and molecular structures of some transition metal-barbiturate complexes Rodgers, Allen Lawrence Nassimbeni, Luigi R Chemistry This thesis describes the synthesis and X-ray structural investigation of four complexes of the type M(II)(barb)₂L₂ where M is a transition metal, barb is the anion of a substituted barbituric acid and L is an organic base. These compounds are of importance in the clinical detection and identification of barbiturate drugs and this aspect is discussed in a later section. An infrared study of these compounds is also described. The individual components of the complexes, viz. the transition metals and the barbiturate ligands are in themselves of great biological and physiological significance. Although the human body is but 3% metals, life depends upon these elements far more than this figure suggests. For example, the transition series metals, even though some are present in only trace amounts, generally appear in the active centres of enzymes that catalyze substrates to form aggregate molecules. The barbiturates on the other hand are members of a group of widely used drugs known as hypnotics, many of which are medicinally applied today. 2016-03-15T07:16:49Z 2016-03-15T07:16:49Z 1974 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/17788 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Rodgers, Allen Lawrence The crystal and molecular structures of some transition metal-barbiturate complexes |
| thesis_degree_str | Doctoral |
| title | The crystal and molecular structures of some transition metal-barbiturate complexes |
| title_full | The crystal and molecular structures of some transition metal-barbiturate complexes |
| title_fullStr | The crystal and molecular structures of some transition metal-barbiturate complexes |
| title_full_unstemmed | The crystal and molecular structures of some transition metal-barbiturate complexes |
| title_short | The crystal and molecular structures of some transition metal-barbiturate complexes |
| title_sort | crystal and molecular structures of some transition metal barbiturate complexes |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/17788 |
| work_keys_str_mv | AT rodgersallenlawrence thecrystalandmolecularstructuresofsometransitionmetalbarbituratecomplexes AT rodgersallenlawrence crystalandmolecularstructuresofsometransitionmetalbarbituratecomplexes |