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Preparation and solid state properties of cyclodextrin complexes of selected drug molecules
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2016
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| _version_ | 1867614493049094144 |
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| access_status_str | Open Access |
| author | Mvula, Eino Natangwe |
| author2 | Caira, Mino R |
| author_browse | Caira, Mino R Mvula, Eino Natangwe |
| author_facet | Caira, Mino R Mvula, Eino Natangwe |
| author_sort | Mvula, Eino Natangwe |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/17902 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:52:54.969Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/17902 Preparation and solid state properties of cyclodextrin complexes of selected drug molecules Mvula, Eino Natangwe Caira, Mino R Chemistry Includes bibliographical references. A large number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin (Trimeb) 3, complexes with clofibric acid as well as the heptakis(2,3,6j·tri-O-methyl)- β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal X-ray analysis. 2016-03-17T07:18:50Z 2016-03-17T07:18:50Z 1999 Master Thesis Masters MSc http://hdl.handle.net/11427/17902 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Mvula, Eino Natangwe Preparation and solid state properties of cyclodextrin complexes of selected drug molecules |
| thesis_degree_str | Master's |
| title | Preparation and solid state properties of cyclodextrin complexes of selected drug molecules |
| title_full | Preparation and solid state properties of cyclodextrin complexes of selected drug molecules |
| title_fullStr | Preparation and solid state properties of cyclodextrin complexes of selected drug molecules |
| title_full_unstemmed | Preparation and solid state properties of cyclodextrin complexes of selected drug molecules |
| title_short | Preparation and solid state properties of cyclodextrin complexes of selected drug molecules |
| title_sort | preparation and solid state properties of cyclodextrin complexes of selected drug molecules |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/17902 |
| work_keys_str_mv | AT mvulaeinonatangwe preparationandsolidstatepropertiesofcyclodextrincomplexesofselecteddrugmolecules |